Dysregulation of chemokine/chemokine receptor axes and NK cell tissue localization during diseases

Giovanni Bernardini, Fabrizio Antonangeli, Valentina Bonanni, Angela Santoni

Research output: Contribution to journalShort surveypeer-review

Abstract

Chemokines are small chemotactic molecules that play key roles in physiological and pathological conditions. Upon signaling via their specific receptors, chemokines regulate tissue mobilization and trafficking of a wide array of immune cells, including natural killer (NK) cells. Current research is focused on analyzing changes in chemokine/chemokine receptor expression during various diseases to interfere with pathological trafficking of cells or to recruit selected cell types to specific tissues. NK cells are a heterogeneous lymphocyte population comprising several subsets endowed with distinct functional properties and mainly representing distinct stages of a linear development process. Because of their different functional potential, the type of subset that accumulates in a tissue drives the final outcome of NK cell-regulated immune response, leading to either protection or pathology. Correspondingly, chemokine receptors, including CXCR4, CXCR3, and CX3CR1, are differentially expressed by NK cell subsets, and their expression levels can be modulated during NK cell activation. At first, this review will summarize the current knowledge on the contribution of chemokines to the localization and generation of NK cell subsets in homeostasis. How an inappropriate chemotactic response can lead to pathology and how chemokine targeting can therapeutically affect tissue recruitment/localization of distinct NK cell subsets will also be discussed.

Original languageEnglish
Article number402
JournalFrontiers in Immunology
Volume7
Issue numberOCT
DOIs
Publication statusPublished - Oct 6 2016

Keywords

  • Chemokine receptors
  • Cross-inhibition
  • CXCR3
  • CXCR4
  • Migration
  • Multiple myeloma
  • Multiple sclerosis
  • NK cell subsets

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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