(E) and (Z)-3-styrylpiperidines as sigma ligands

Sergio Mantegani, Enzo Brambilla, Paolo Cremonesi, Carla Caccia, Maria Gioia Fornaretto, Nicola Carfagna, Monica Colombo, Robert A. McArthur, Mario Varasi

Research output: Contribution to journalArticlepeer-review

Abstract

A class of (E) and Q-3-styrylpiperidine derivatives was prepared as racemates and evaluated for affinity at σ binding sites labeled with [3H]-(±-SKF-10,047. Some of these compounds exhibited high affinity and selectivity for σ verus D1 and D2 binding sites.

Original languageEnglish
Pages (from-to)1525-1530
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number12
DOIs
Publication statusPublished - Jun 17 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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