E-cadherin and Hakai: Signalling, remodeling or destruction?

Salvatore Pece, J. Silvio Gutkind

Research output: Contribution to journalArticlepeer-review


Activation of tyrosine kinase receptors in epithelial cells results in the rapid disassembly of E-cadherin-mediated cell-cell adhesions. New research has identified Hakai, an E3-ubiquitin-ligase related to Cbl that binds E-cadherin in a tyrosine phosphorylation-dependent manner. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai may control epithelial-mesenchymal transitions under physiological and pathological conditions.

Original languageEnglish
JournalNature Cell Biology
Issue number4
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Cell Biology


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