E-cadherin deregulation in breast cancer

Giovanni Corso, Joana Figueiredo, Simone Pietro De Angelis, Federica Corso, Antonia Girardi, Joana Pereira, Raquel Seruca, Bernardo Bonanni, Patricia Carneiro, Gabriella Pravettoni, Elena Guerini Rocco, Paolo Veronesi, Giacomo Montagna, Virgilio Sacchini, Sara Gandini

Research output: Contribution to journalReview articlepeer-review

Abstract

E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.

Original languageEnglish
Pages (from-to)5930-5936
Number of pages7
JournalJournal of Cellular and Molecular Medicine
Volume24
Issue number11
DOIs
Publication statusPublished - Jun 1 2020

Keywords

  • breast cancer
  • breast cancer metastases
  • breast cancer prognosis
  • breast cancer survival
  • E-cadherin

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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