E-cadherin loss and ΔNP73L expression in oral squamous cell carcinomas showing aggressive behavior

Maria P. Foschini, Roberto Cocchi, Luca Morandi, Gianluca Marucci, Maria G. Pennesi, Alberto Righi, Anna L. Tosi, Dario De Biase, Annalisa Pession, Lucio Montebugnoli

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Abstract

Background. This article sought to investigate the existence of parameters useful for predicting lymph node metastases in cases of surgically resected oral squamous cell carcinomas (OSCCs). Methods. Fifty-eight cases were studied for E-cadherin and the truncated dominant-negative isoform of p63 (ΔNp63) with immunohistochemistry. In addition, the p63 gene expression profile was evaluated by reverse transcriptase-polymerase chain reaction (RTPCR) to disclose the presence of the truncated variant ΔNp73L. Results. E-cadherin expression was the most powerful parameter related to the presence of lymph node metastases at presentation. Twenty-four of 38 (63%) cases showing low E-cadherin expression had lymph node metastases at presentation compared with 5 of 20 (25%) (p

Original languageEnglish
Pages (from-to)1475-1482
Number of pages8
JournalHead and Neck
Volume30
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords

  • ΔNp73L
  • E-cadherin
  • Lymph node metastasis
  • p63
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Foschini, M. P., Cocchi, R., Morandi, L., Marucci, G., Pennesi, M. G., Righi, A., Tosi, A. L., De Biase, D., Pession, A., & Montebugnoli, L. (2008). E-cadherin loss and ΔNP73L expression in oral squamous cell carcinomas showing aggressive behavior. Head and Neck, 30(11), 1475-1482. https://doi.org/10.1002/hed.20908