E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

Daniela Galimberti; Chiara Fenoglio; Raffaella Clerici; Cristoforo Comi; Milena De Riz; Mariarosa Rottoli; Laura Piccio; Marco Ronzoni; Eliana Venturelli; Francesco Monaco; Marco Poloni; Nereo Bresolin; Elio Scarpini

doi:10.1016/j.jneuroim.2005.05.003

E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

Daniela Galimberti, Chiara Fenoglio, Raffaella Clerici, Cristoforo Comi, Milena De Riz, Mariarosa Rottoli, Laura Piccio, Marco Ronzoni, Eliana Venturelli, Francesco Monaco, Marco Poloni, Nereo Bresolin, Elio Scarpini

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

Original language	English
Pages (from-to)	201-205
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	165
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.05.003
Publication status	Published - Aug 2005

Keywords

Adhesion molecules
E-selectin
Genetics
Multiple sclerosis
Polymorphism

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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Galimberti, D., Fenoglio, C., Clerici, R., Comi, C., De Riz, M., Rottoli, M., Piccio, L., Ronzoni, M., Venturelli, E., Monaco, F., Poloni, M., Bresolin, N., & Scarpini, E. (2005). E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis. Journal of Neuroimmunology, 165(1-2), 201-205. https://doi.org/10.1016/j.jneuroim.2005.05.003

E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis. / Galimberti, Daniela; Fenoglio, Chiara; Clerici, Raffaella; Comi, Cristoforo; De Riz, Milena; Rottoli, Mariarosa; Piccio, Laura; Ronzoni, Marco; Venturelli, Eliana; Monaco, Francesco; Poloni, Marco; Bresolin, Nereo ; Scarpini, Elio.

In: Journal of Neuroimmunology, Vol. 165, No. 1-2, 08.2005, p. 201-205.

Research output: Contribution to journal › Article › peer-review

Galimberti, D, Fenoglio, C, Clerici, R, Comi, C, De Riz, M, Rottoli, M, Piccio, L, Ronzoni, M, Venturelli, E, Monaco, F, Poloni, M, Bresolin, N & Scarpini, E 2005, 'E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis', Journal of Neuroimmunology, vol. 165, no. 1-2, pp. 201-205. https://doi.org/10.1016/j.jneuroim.2005.05.003

Galimberti, Daniela ; Fenoglio, Chiara ; Clerici, Raffaella ; Comi, Cristoforo ; De Riz, Milena ; Rottoli, Mariarosa ; Piccio, Laura ; Ronzoni, Marco ; Venturelli, Eliana ; Monaco, Francesco ; Poloni, Marco ; Bresolin, Nereo ; Scarpini, Elio. / E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis. In: Journal of Neuroimmunology. 2005 ; Vol. 165, No. 1-2. pp. 201-205.

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abstract = "Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.",

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AU - De Riz, Milena

AU - Rottoli, Mariarosa

AU - Piccio, Laura

AU - Ronzoni, Marco

AU - Venturelli, Eliana

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AU - Poloni, Marco

AU - Bresolin, Nereo

AU - Scarpini, Elio

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AB - Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

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