Abstract
Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.
Original language | English |
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Pages (from-to) | 201-205 |
Number of pages | 5 |
Journal | Journal of Neuroimmunology |
Volume | 165 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Aug 2005 |
Keywords
- Adhesion molecules
- E-selectin
- Genetics
- Multiple sclerosis
- Polymorphism
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology