E2F target genes: Unraveling the biology

Adrian P. Bracken, Marco Ciro, Andrea Cocito, Kristian Helin

Research output: Contribution to journalArticle

359 Citations (Scopus)

Abstract

The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.

Original languageEnglish
Pages (from-to)409-417
Number of pages9
JournalTrends in Biochemical Sciences
Volume29
Issue number8
DOIs
Publication statusPublished - Aug 2004

Fingerprint

DNA Replication
Cell Cycle
Genes
E2F Transcription Factors
Retinoblastoma Protein
Essential Genes
DNA Repair
DNA Damage
DNA
Homeostasis
Cells
Genome
Apoptosis
Transcription
Repair

ASJC Scopus subject areas

  • Biochemistry

Cite this

Bracken, A. P., Ciro, M., Cocito, A., & Helin, K. (2004). E2F target genes: Unraveling the biology. Trends in Biochemical Sciences, 29(8), 409-417. https://doi.org/10.1016/j.tibs.2004.06.006

E2F target genes : Unraveling the biology. / Bracken, Adrian P.; Ciro, Marco; Cocito, Andrea; Helin, Kristian.

In: Trends in Biochemical Sciences, Vol. 29, No. 8, 08.2004, p. 409-417.

Research output: Contribution to journalArticle

Bracken, AP, Ciro, M, Cocito, A & Helin, K 2004, 'E2F target genes: Unraveling the biology', Trends in Biochemical Sciences, vol. 29, no. 8, pp. 409-417. https://doi.org/10.1016/j.tibs.2004.06.006
Bracken, Adrian P. ; Ciro, Marco ; Cocito, Andrea ; Helin, Kristian. / E2F target genes : Unraveling the biology. In: Trends in Biochemical Sciences. 2004 ; Vol. 29, No. 8. pp. 409-417.
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