Abstract
The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.
| Original language | English |
|---|---|
| Pages (from-to) | 409-417 |
| Number of pages | 9 |
| Journal | Trends in Biochemical Sciences |
| Volume | 29 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2004 |
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ASJC Scopus subject areas
- Biochemistry
Cite this
E2F target genes : Unraveling the biology. / Bracken, Adrian P.; Ciro, Marco; Cocito, Andrea; Helin, Kristian.
In: Trends in Biochemical Sciences, Vol. 29, No. 8, 08.2004, p. 409-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - E2F target genes
T2 - Unraveling the biology
AU - Bracken, Adrian P.
AU - Ciro, Marco
AU - Cocito, Andrea
AU - Helin, Kristian
PY - 2004/8
Y1 - 2004/8
N2 - The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.
AB - The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=4043163461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4043163461&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2004.06.006
DO - 10.1016/j.tibs.2004.06.006
M3 - Article
C2 - 15362224
AN - SCOPUS:4043163461
VL - 29
SP - 409
EP - 417
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0376-5067
IS - 8
ER -