E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

Heiko Müller, Adrian P. Bracken, Richard Vernell, M. Cristina Moroni, Fred Christians, Emanuela Grassilli, Elena Prosperini, Elena Vigo, Jonathan D. Oliner, Kristian Helin

Research output: Contribution to journalArticlepeer-review

Abstract

The retinoblastoma protein (pRB) and its two relatives, p107 and p130, regulate development and cell proliferation in part by inhibiting the activity of E2F-regulated promoters. We have used high-density oligonucleotide arrays to identify genes in which expression changed in response to activation of E2F1, E2F2, and E2F3. We show that the E2Fs control the expression of several genes that are involved in cell proliferation. We also show that the E2Fs regulate a number of genes involved in apoptosis, differentiation, and development. These results provide possible genetic explanations to the variety of phenotypes observed as a consequence of a deregulated pRB/E2F pathway.

Original languageEnglish
Pages (from-to)267-285
Number of pages19
JournalGenes and Development
Volume15
Issue number3
DOIs
Publication statusPublished - Feb 1 2001

Keywords

  • E2F
  • Microarray
  • Retinoblastoma
  • Target gene bias

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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