E6/E7 mRNA testing for human papilloma virus-induced high-grade cervical intraepithelial disease (CIN2/CIN3): A promising perspective

Massimo Origoni, Paolo Cristoforoni, Guia Carminati, Chiara Stefani, Silvano Costa, Maria Teresa Sandri, Luciano Mariani, Mario Preti

Research output: Contribution to journalArticle

Abstract

Since the introduction of biomolecular testing for the identification of high-risk human papillomavirus DNA (hrHPV-DNA) in cervical cancer preventive strategies, many interesting aspects have emerged in this field; firstly, HPV-DNA testing has been demonstrated to have better sensitivity than conventional cytology in several settings: screening, triage of ASC-US and in follow-up after treatment. Despite this, some limitations of these new technologies have also been underlined: the major issue is the low specificity of the tests, which cannot discriminate between regressive and progressive infections. Thus, recent research has moved the attention towards novel markers of progression that could more precisely detect cases at real risk of cancer development. In view of the fact that progression to cancer is dependable of the E6/E7 proteins integration and transforming action, the overexpression of E6/E7 transcripts has been seen as a valuable marker of this risk. This review aims to summarise the literature data on this topic and to provide a clear view of the emerging perspectives.

Original languageEnglish
Article number533
Journalecancermedicalscience
Volume9
DOIs
Publication statusPublished - Apr 29 2015

Keywords

  • Cervical cancer
  • E6
  • E7
  • HPV
  • HPV-DNA
  • Human papillomavirus
  • mRNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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