EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry I: Blood and bone marrow dosimetry in differentiated thyroid cancer therapy

Michael Lassmann, Heribert Hänscheid, Carlo Chiesa, Cecilia Hindorf, Glenn Flux, Markus Luster

Research output: Contribution to journalArticle

Abstract

Introduction: The purpose of the EANM Dosimetry Committee Series on "Standard Operational Procedures for Pre-therapeutic Dosimetry" (SOP) is to provide advice to scientists and clinicians on how to perform pre-therapeutic and/or therapeutic patient-specific absorbed dose assessments. Material and Methods: This particular SOP gives advice on how to tailor the therapeutic activity to be administered for systemic treatment of differentiated thyroid cancer (DTC) such that the absorbed dose to the blood does not exceed 2 Gy (a widely accepted limit for bone marrow toxicity). The methodology of blood-based dosimetry has been developed in the 1960s and refined in a series of international multi-centre trials in the framework of the introduction of new diagnostic and therapeutic tools, e.g. recombinant human thyroid-stimulating hormone in the management of DTC. Conclusion: The intention is to guide the user through a series of measurements and calculations which the authors consider to be the best and most reproducible way at present.

Original languageEnglish
Pages (from-to)1405-1412
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume35
Issue number7
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Dosimetry
  • SOP
  • Thyroid cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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