Early (≤1-h) vs. late (>1-h) administration of frovatriptan plus dexketoprofen combination vs. frovatriptan monotherapy in the acute treatment of migraine attacks with or without aura: a post hoc analysis of a double-blind, randomized, parallel group study

Gianni Allais, Gennaro Bussone, Vincenzo Tullo, Pietro Cortelli, Fabio Valguarnera, Piero Barbanti, Giuliano Sette, Fabio Frediani, Giacomo D’Arrigo, Florindo d’Onofrio, Giancarlo Comi, Marcella Curone, Bruno Colombo, Stefano Omboni, Chiara Benedetto

Research output: Contribution to journalArticlepeer-review

Abstract

The early use of triptan in combination with a nonsteroidal anti-inflammatory drug after headache onset may improve the efficacy of acute migraine treatment. In this retrospective analysis of a randomized, double-blind, parallel group study, we assessed the efficacy of early or late intake of frovatriptan 2.5 mg + dexketoprofen 25 or 37.5 mg (FroDex 25 and FroDex 37.5) vs. frovatriptan 2.5 mg alone (Frova) in the acute treatment of migraine attacks. In this double-blind, randomized parallel group study 314 subjects with acute migraine with or without aura were randomly assigned to Frova, FroDex 25, or FroDex 37.5. Pain free (PF) at 2-h (primary endpoint), PF at 4-h and pain relief (PR) at 2 and 4-h, speed of onset at 60, 90, 120 and 240-min, and sustained pain free (SPF) at 24-h were compared across study groups according to early (≤1-h; n = 220) or late (>1-h; n = 59) intake. PF rates at 2 and 4-h were significantly larger with FroDex 37.5 vs. Frova (early intake, n = 71 FroDex 37.5 and n = 75 Frova: 49 vs. 32 % and 68 vs. 52 %, p 

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalNeurological Sciences
Volume36
DOIs
Publication statusPublished - May 30 2015

Keywords

  • Dexketoprofen
  • Early use
  • Frovatriptan
  • Late use
  • Migraine

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)

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