Early abnormalities of the antibody response against Mycobacterium tuberculosis in human immunodeficiency virus infection

Cesare Saltini, Massimo Amicosante, Enrico Girardi, Giorgio Antonucci, Giuseppe Ippolito, Franco Ameglio, Laura Monno, Pierpaolo Congedo, Gioacchino Angarano, Sergio Babudieri, Giovanni Guaraldi, Giuseppe Visco, Enza Piccolella, Gregorino Paone, Giovanni Pallotta, Alberto Bisetti

Research output: Contribution to journalArticle

Abstract

Among human immunodeficiency virus (HIV)-infected persons, those who react against purified protein derivative (PPD) have higher risk of tuberculosis. Since PPD testing has limited predictive power in HIV-positive populations, new markers of antituberculous immunity were sought by analyzing antibodies to Mycobacterium tuberculosis antigens (PPD and its fraction A60) in 102 HIV-positive subjects, some PPD-positive and some PPD-negative, and in 23 HIV-positive tuberculosis patients. ELISA and Western blotting were used. Forty HIV-negative healthy subjects and 40 HIV-negative tuberculosis patients were evaluated as controls. While all those HIV-negative and PPD-positive had IgG antibodies recognizing the 38-, 28-, and 19-kDa M. tuberculosis antigens, only 26% of those HIV-positive and PPD-positive (all with + cells/mm3) and none of the HIV-positive tuberculosis patients recognized them, indicating that the lack of IgG against those antigens, in the presence of a specific IgM response, is a marker of immunodeficiency.

Original languageEnglish
Pages (from-to)1409-1414
Number of pages6
JournalJournal of Infectious Diseases
Volume168
Issue number6
Publication statusPublished - Dec 1993

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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    Saltini, C., Amicosante, M., Girardi, E., Antonucci, G., Ippolito, G., Ameglio, F., Monno, L., Congedo, P., Angarano, G., Babudieri, S., Guaraldi, G., Visco, G., Piccolella, E., Paone, G., Pallotta, G., & Bisetti, A. (1993). Early abnormalities of the antibody response against Mycobacterium tuberculosis in human immunodeficiency virus infection. Journal of Infectious Diseases, 168(6), 1409-1414.