Early activation signals in endothelial cells: Stimulation by cytokines

Martino Introna, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review


With limitation to the 'proinflammatory program' induced in endothelial cells by exposure to interleukin-1, tumor necrosis factor, and interleukin- 6, we review the available data on the signaling for these three cytokines, from receptor engagement to induction of gene transcription. Only a few molecular pathways have been characterized so far, and key issues in endothelial biology, such as endothelial specificity of gene expression and heterogeneity of different endothelial populations, remain largely unexplored.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number3
Publication statusPublished - 1997


  • cytokines
  • endothelial cells
  • gene expression
  • molecular signaling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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