Early add-on immunoglobulin administration in Rasmussen encephalitis: The hypothesis of neuroimmunomodulation

L. Papetti, F. Nicita, T. Granata, R. Guerrini, F. Ursitti, E. Properzi, P. Iannetti, A. Spalice

Research output: Contribution to journalArticle

Abstract

Rasmussen encephalitis (RE) is a chronic inflammatory disease leading to unilateral hemispheric atrophy, associated with progressive neurological dysfunction and intractable seizures. The best approach to RE is hemispherectomy. However long-term immunotherapy seems to prevent or slow down hemispheric tissue loss and the associated functional decline.We describe a girl with epilepsia partialis continua (EPC) and progressive neurological dysfunction compatible with RE. The brain MRI showed a lesion that was initially interpreted as focal cortical dysplasia. Combined antiepileptic and immunomodulation were administered for two years with initial beneficial effects. The follow-up MRI, 4 year later showed. atrophic change in right parietal region.The association of antiepileptic and immunomodulation therapies may inhibit pathogenetic mechanisms responsible for neuronal loss in RE, slowing down the progression of the disease.

Original languageEnglish
Pages (from-to)917-920
Number of pages4
JournalMedical Hypotheses
Volume77
Issue number5
DOIs
Publication statusPublished - Nov 2011

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Neuroimmunomodulation
Encephalitis
Immunoglobulins
Immunomodulation
Anticonvulsants
Epilepsia Partialis Continua
Hemispherectomy
Malformations of Cortical Development
Parietal Lobe
Immunotherapy
Atrophy
Disease Progression
Seizures
Chronic Disease
Brain

ASJC Scopus subject areas

  • Medicine(all)

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Early add-on immunoglobulin administration in Rasmussen encephalitis : The hypothesis of neuroimmunomodulation. / Papetti, L.; Nicita, F.; Granata, T.; Guerrini, R.; Ursitti, F.; Properzi, E.; Iannetti, P.; Spalice, A.

In: Medical Hypotheses, Vol. 77, No. 5, 11.2011, p. 917-920.

Research output: Contribution to journalArticle

Papetti, L. ; Nicita, F. ; Granata, T. ; Guerrini, R. ; Ursitti, F. ; Properzi, E. ; Iannetti, P. ; Spalice, A. / Early add-on immunoglobulin administration in Rasmussen encephalitis : The hypothesis of neuroimmunomodulation. In: Medical Hypotheses. 2011 ; Vol. 77, No. 5. pp. 917-920.
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