Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT: a pilot study on semiquantitative and computer-aided fractal geometry analysis

Egesta Lopci, Fabio Grizzi, Carlo Russo, Luca Toschi, Ilaria Grassi, Gianfranco Cicoria, Filippo Lodi, Sandro Mattioli, Stefano Fanti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses.

PATIENTS AND METHODS: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with Cu-ATSM PET/CT. Participants received an intravenous injection of Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension.

RESULTS: All tumour lesions showed increased uptake of Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm (range: 2.8-453.7) and a median HB of 161.5 cm (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05).

CONCLUSION: Our findings support the consistency of Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.

Original languageEnglish
Pages (from-to)340-346
Number of pages7
JournalNuclear Medicine Communications
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 2017

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Fractals
Neoplasms
Head and Neck Neoplasms
Muscles
Diacetyl
Body Size
Non-Small Cell Lung Carcinoma
Intravenous Injections
Copper
Software
copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)

Keywords

  • Aged
  • Carcinoma, Non-Small-Cell Lung
  • Copper Radioisotopes
  • Female
  • Fractals
  • Head and Neck Neoplasms
  • Humans
  • Image Interpretation, Computer-Assisted
  • Lung Neoplasms
  • Male
  • Middle Aged
  • Organometallic Compounds
  • Pilot Projects
  • Positron Emission Tomography Computed Tomography
  • Radiopharmaceuticals
  • Thiosemicarbazones
  • Evaluation Studies
  • Journal Article

Cite this

Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT : a pilot study on semiquantitative and computer-aided fractal geometry analysis. / Lopci, Egesta; Grizzi, Fabio; Russo, Carlo; Toschi, Luca; Grassi, Ilaria; Cicoria, Gianfranco; Lodi, Filippo; Mattioli, Sandro; Fanti, Stefano.

In: Nuclear Medicine Communications, Vol. 38, No. 4, 04.2017, p. 340-346.

Research output: Contribution to journalArticle

Lopci, Egesta ; Grizzi, Fabio ; Russo, Carlo ; Toschi, Luca ; Grassi, Ilaria ; Cicoria, Gianfranco ; Lodi, Filippo ; Mattioli, Sandro ; Fanti, Stefano. / Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT : a pilot study on semiquantitative and computer-aided fractal geometry analysis. In: Nuclear Medicine Communications. 2017 ; Vol. 38, No. 4. pp. 340-346.
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abstract = "OBJECTIVE: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses.PATIENTS AND METHODS: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with Cu-ATSM PET/CT. Participants received an intravenous injection of Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension.RESULTS: All tumour lesions showed increased uptake of Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm (range: 2.8-453.7) and a median HB of 161.5 cm (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05).CONCLUSION: Our findings support the consistency of Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.",
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T1 - Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT

T2 - a pilot study on semiquantitative and computer-aided fractal geometry analysis

AU - Lopci, Egesta

AU - Grizzi, Fabio

AU - Russo, Carlo

AU - Toschi, Luca

AU - Grassi, Ilaria

AU - Cicoria, Gianfranco

AU - Lodi, Filippo

AU - Mattioli, Sandro

AU - Fanti, Stefano

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N2 - OBJECTIVE: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses.PATIENTS AND METHODS: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with Cu-ATSM PET/CT. Participants received an intravenous injection of Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension.RESULTS: All tumour lesions showed increased uptake of Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm (range: 2.8-453.7) and a median HB of 161.5 cm (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05).CONCLUSION: Our findings support the consistency of Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.

AB - OBJECTIVE: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses.PATIENTS AND METHODS: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with Cu-ATSM PET/CT. Participants received an intravenous injection of Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension.RESULTS: All tumour lesions showed increased uptake of Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm (range: 2.8-453.7) and a median HB of 161.5 cm (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05).CONCLUSION: Our findings support the consistency of Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.

KW - Aged

KW - Carcinoma, Non-Small-Cell Lung

KW - Copper Radioisotopes

KW - Female

KW - Fractals

KW - Head and Neck Neoplasms

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Lung Neoplasms

KW - Male

KW - Middle Aged

KW - Organometallic Compounds

KW - Pilot Projects

KW - Positron Emission Tomography Computed Tomography

KW - Radiopharmaceuticals

KW - Thiosemicarbazones

KW - Evaluation Studies

KW - Journal Article

U2 - 10.1097/MNM.0000000000000656

DO - 10.1097/MNM.0000000000000656

M3 - Article

C2 - 28263239

VL - 38

SP - 340

EP - 346

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

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ER -