Early and late neutropenia in children treated with cotrimoxazole (trimethoprim-sulfamethoxazole)

N. Principi, P. Marchisio, A. Biasini, A. Dalla Villa

Research output: Contribution to journalArticle

Abstract

The incidence of hematologic abnormalities was evaluated in 120 children with otitis media treated respectively with cotrimoxazole (trimethoprim-sulfamethoxazole) (group 1), cotrimoxazole plus folinic acid (group 2) and amoxicillin (group 3) in therapeutic doses for ten days. Only eosinophilia (an absolute count ≥ 0.5 x 109/l) (group 1=10%, 2=5%, 3=7.5%) and neutropenia (polymorphonuclear neutrophilic leucocyte count ≤1.5 x 109/1) (group 1=35%, 2=17.5%, 3=13.3%) were noted. Early neutropenia (evident on the 5th day of therapy) occurred in all the treatment groups, thus it is not related to cotrinoxazole administration and in most cases neutrophil count reversed to normal in few days without drug discontinuation. Late neutropenia (evident after 10 days of treatment) appeared only in cotrimoxazole treated children (p

Original languageEnglish
Pages (from-to)763-767
Number of pages5
JournalActa Paediatrica Scandinavica
Volume73
Issue number6
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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