Early and multifocal tumors in breast, salivary, Harderian and epididymal tissues developed in MMTY-Neu transgenic mice

Franco Lucchini, Maria Grazia Sacco, Nanpin Hu, Anna Villa, John Brown, Luigi Cesano, Laura Mangiarini, Guido Rindi, Sandra Kindl, Fausto Sessa, Paolo Vezzoni, Libero Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

Transgenic mice carrying various oncogenes driven by mammary gland specific enhancers develop mammary tumors usually arising in a stochastic way. The only exception is a mouse lineage (TG.NF) carrying an activated rat Neu oncogene driven by the murine mammary tumor virus long terminal repeat (MMTV-LTR) that gave rise to rapid and multifocal mammary tumors interpreted as a result of a single-step neoplastic transformation. The effect of the oncogene appeared to be specific for breast tissue, since salivary and Harderian glands as well as epididymis expressed high levels of Neu but only developed hyperplasia (Muller et al., Cell, (1988) 54, p. 105). Here we describe a transgenic mouse lineage for the MMTV-Neu, analysed up to third generation. Multifocal tumors involving mammary glands arose very rapidly in all females independently from pregnancy and in some males. Moreover, multifocal neoplasias occurred also in salivary and Harderian glands and in the epididymis at a very high rate. These data demonstrate that the Neu oncogene can induce tumors in all the tissues where it is expressed at high levels.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalCancer Letters
Volume64
Issue number3
DOIs
Publication statusPublished - Jul 10 1992

Keywords

  • breast tumors
  • multifocality
  • oncogenes
  • salivary tumors
  • transgenic mice

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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