Early and Phasic Cortical Metabolic Changes in Vestibular Neuritis Onset

Marco Alessandrini, Marco Pagani, Bianca Napolitano, Alessandro Micarelli, Matteo Candidi, Ernesto Bruno, Agostino Chiaravalloti, Barbara Di Pietro, Orazio Schillaci

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Functional brain activation studies described the presence of separate cortical areas responsible for central processing of peripheral vestibular information and reported their activation and interactions with other sensory modalities and the changes of this network associated to strategic peripheral or central vestibular lesions. It is already known that cortical changes induced by acute unilateral vestibular failure (UVF) are various and undergo variations over time, revealing different cortical involved areas at the onset and recovery from symptoms. The present study aimed at reporting the earliest change in cortical metabolic activity during a paradigmatic form of UVF such as vestibular neuritis (VN), that is, a purely peripheral lesion of the vestibular system, that offers the opportunity to study the cortical response to altered vestibular processing. This research reports [18F]fluorodeoxyglucose positron emission tomography brain scan data concerning the early cortical metabolic activity associated to symptoms onset in a group of eight patients suffering from VN. VN patients' cortical metabolic activity during the first two days from symptoms onset was compared to that recorded one month later and to a control healthy group. Beside the known cortical response in the sensorimotor network associated to vestibular deafferentation, we show for the first time the involvement of Entorhinal (BAs 28, 34) and Temporal (BA 38) cortices in early phases of symptomatology onset. We interpret these findings as the cortical counterparts of the attempt to reorient oneself in space counteracting the vertigo symptom (Bas 28, 34) and of the emotional response to the new pathologic condition (BA 38) respectively. These interpretations were further supported by changes in patients' subjective ratings in balance, anxiety, and depersonalization/derealization scores when tested at illness onset and one month later. The present findings contribute in expanding knowledge about early, fast-changing, and complex cortical responses to pathological vestibular unbalanced processing.

Original languageEnglish
Article numbere57596
JournalPLoS One
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 7 2013

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Vestibular Neuronitis
signs and symptoms (animals and humans)
Depersonalization
Brain
Processing
Chemical activation
lesions (animal)
Positron emission tomography
Vertigo
Fluorodeoxyglucose F18
brain
positron-emission tomography
Positron-Emission Tomography
anxiety
Anxiety
Recovery
cortex
Control Groups

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Alessandrini, M., Pagani, M., Napolitano, B., Micarelli, A., Candidi, M., Bruno, E., ... Schillaci, O. (2013). Early and Phasic Cortical Metabolic Changes in Vestibular Neuritis Onset. PLoS One, 8(3), [e57596]. https://doi.org/10.1371/journal.pone.0057596

Early and Phasic Cortical Metabolic Changes in Vestibular Neuritis Onset. / Alessandrini, Marco; Pagani, Marco; Napolitano, Bianca; Micarelli, Alessandro; Candidi, Matteo; Bruno, Ernesto; Chiaravalloti, Agostino; Di Pietro, Barbara; Schillaci, Orazio.

In: PLoS One, Vol. 8, No. 3, e57596, 07.03.2013.

Research output: Contribution to journalArticle

Alessandrini, M, Pagani, M, Napolitano, B, Micarelli, A, Candidi, M, Bruno, E, Chiaravalloti, A, Di Pietro, B & Schillaci, O 2013, 'Early and Phasic Cortical Metabolic Changes in Vestibular Neuritis Onset', PLoS One, vol. 8, no. 3, e57596. https://doi.org/10.1371/journal.pone.0057596
Alessandrini M, Pagani M, Napolitano B, Micarelli A, Candidi M, Bruno E et al. Early and Phasic Cortical Metabolic Changes in Vestibular Neuritis Onset. PLoS One. 2013 Mar 7;8(3). e57596. https://doi.org/10.1371/journal.pone.0057596
Alessandrini, Marco ; Pagani, Marco ; Napolitano, Bianca ; Micarelli, Alessandro ; Candidi, Matteo ; Bruno, Ernesto ; Chiaravalloti, Agostino ; Di Pietro, Barbara ; Schillaci, Orazio. / Early and Phasic Cortical Metabolic Changes in Vestibular Neuritis Onset. In: PLoS One. 2013 ; Vol. 8, No. 3.
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