Early aphasia rehabilitation is associated with functional reactivation of the left inferior frontal gyrus a pilot study

Flavia Mattioli, Claudia Ambrosi, Lorella Mascaro, Cristina Scarpazza, Patrizia Pasquali, Marina Frugoni, Mauro Magoni, Laura Biagi, Roberto Gasparotti

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Purpose - Early poststroke aphasia rehabilitation effects and their functional MRI (fMRI) correlates were investigated in a pilot, controlled longitudinal study. Methods - Twelve patients with mild/moderate aphasia (8 Broca, 3 anomic, and 1 Wernicke) were randomly assigned to daily language rehabilitation for 2 weeks (starting 2.2 [mean] days poststroke) or no rehabilitation. The Aachen Aphasia Test and fMRI recorded during an auditory comprehension task were performed at 3 time intervals: mean 2.2 (T1), 16.2 (T2), and 190 (T3) days poststroke. Results - Groups did not differ in terms of age, education, aphasia severity, lesions volume, baseline fMRI activations, and in task performance during fMRI across examinations. Rehabilitated patients significantly improved in naming and written language tasks (P

Original languageEnglish
Pages (from-to)545-552
Number of pages8
JournalStroke
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Aphasia
  • Language therapy
  • Magnetic resonance imaging, functional
  • Neuroimaging
  • Rehabilitation outcome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

Fingerprint Dive into the research topics of 'Early aphasia rehabilitation is associated with functional reactivation of the left inferior frontal gyrus a pilot study'. Together they form a unique fingerprint.

Cite this