Abstract
We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P
Original language | English |
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Pages (from-to) | 453-459 |
Number of pages | 7 |
Journal | Hypertension |
Volume | 25 |
Issue number | 3 |
Publication status | Published - 1995 |
Keywords
- blood pressure
- bradykinin
- kallikrein-kinin system
- kidney
- phenotype
ASJC Scopus subject areas
- Internal Medicine