Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats

P. Madeddu, P. P. Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, V. Anania, N. Glorioso

Research output: Contribution to journalArticle

Abstract

We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P

Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalHypertension
Volume25
Issue number3
Publication statusPublished - 1995

Keywords

  • blood pressure
  • bradykinin
  • kallikrein-kinin system
  • kidney
  • phenotype

ASJC Scopus subject areas

  • Internal Medicine

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