Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats

P. Madeddu; P. P. Parpaglia; M. P. Demontis; M. V. Varoni; M. C. Fattaccio; V. Anania; N. Glorioso

Early blockade of bradykinin B₂-receptors alters the adult cardiovascular phenotype in rats

P. Madeddu, P. P. Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, V. Anania, N. Glorioso

IRCCS Multimedica

Research output: Contribution to journal › Article

Abstract

We evaluated whether long-term inhibition of bradykinin B₂-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp³,Thi⁵,D-Tic⁷,Oic⁸]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P

Original language	English
Pages (from-to)	453-459
Number of pages	7
Journal	Hypertension
Volume	25
Issue number	3
Publication status	Published - 1995

Keywords

blood pressure
bradykinin
kallikrein-kinin system
kidney
phenotype

ASJC Scopus subject areas

Internal Medicine

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title = "Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats",

abstract = "We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P",

keywords = "blood pressure, bradykinin, kallikrein-kinin system, kidney, phenotype",

author = "P. Madeddu and Parpaglia, {P. P.} and Demontis, {M. P.} and Varoni, {M. V.} and Fattaccio, {M. C.} and V. Anania and N. Glorioso",

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T1 - Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats

AU - Madeddu, P.

AU - Parpaglia, P. P.

AU - Demontis, M. P.

AU - Varoni, M. V.

AU - Fattaccio, M. C.

AU - Anania, V.

AU - Glorioso, N.

PY - 1995

Y1 - 1995

N2 - We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P

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