Abstract
We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P
| Original language | English |
|---|---|
| Pages (from-to) | 453-459 |
| Number of pages | 7 |
| Journal | Hypertension |
| Volume | 25 |
| Issue number | 3 |
| Publication status | Published - 1995 |
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Keywords
- blood pressure
- bradykinin
- kallikrein-kinin system
- kidney
- phenotype
ASJC Scopus subject areas
- Internal Medicine
Cite this
Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats. / Madeddu, P.; Parpaglia, P. P.; Demontis, M. P.; Varoni, M. V.; Fattaccio, M. C.; Anania, V.; Glorioso, N.
In: Hypertension, Vol. 25, No. 3, 1995, p. 453-459.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats
AU - Madeddu, P.
AU - Parpaglia, P. P.
AU - Demontis, M. P.
AU - Varoni, M. V.
AU - Fattaccio, M. C.
AU - Anania, V.
AU - Glorioso, N.
PY - 1995
Y1 - 1995
N2 - We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P
AB - We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P
KW - blood pressure
KW - bradykinin
KW - kallikrein-kinin system
KW - kidney
KW - phenotype
UR - http://www.scopus.com/inward/record.url?scp=0028955928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028955928&partnerID=8YFLogxK
M3 - Article
VL - 25
SP - 453
EP - 459
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 3
ER -