Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats

P. Madeddu, P. P. Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, V. Anania, N. Glorioso

Research output: Contribution to journalArticle

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Abstract

We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]- bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their offspring maintained on Hoe 140 and a normal sodium diet. Controls were given vehicle instead of Hoe 140. At 9 weeks of age, rats given Hoe 140 during prenatal and postnatal phases of life showed greater systolic pressures, heart rates, and body weights than controls (122±1 versus 113±1 mmHg, 444±6 versus 395±8 beats per minute, 258±7 versus 213±3 g, respectively, P

Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalHypertension
Volume25
Issue number3
Publication statusPublished - 1995

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Bradykinin B2 Receptors
Phenotype
Blood Pressure
Sodium
Bradykinin
Heart Rate
Body Weight
Diet

Keywords

  • blood pressure
  • bradykinin
  • kallikrein-kinin system
  • kidney
  • phenotype

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Madeddu, P., Parpaglia, P. P., Demontis, M. P., Varoni, M. V., Fattaccio, M. C., Anania, V., & Glorioso, N. (1995). Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats. Hypertension, 25(3), 453-459.

Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats. / Madeddu, P.; Parpaglia, P. P.; Demontis, M. P.; Varoni, M. V.; Fattaccio, M. C.; Anania, V.; Glorioso, N.

In: Hypertension, Vol. 25, No. 3, 1995, p. 453-459.

Research output: Contribution to journalArticle

Madeddu, P, Parpaglia, PP, Demontis, MP, Varoni, MV, Fattaccio, MC, Anania, V & Glorioso, N 1995, 'Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats', Hypertension, vol. 25, no. 3, pp. 453-459.
Madeddu P, Parpaglia PP, Demontis MP, Varoni MV, Fattaccio MC, Anania V et al. Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats. Hypertension. 1995;25(3):453-459.
Madeddu, P. ; Parpaglia, P. P. ; Demontis, M. P. ; Varoni, M. V. ; Fattaccio, M. C. ; Anania, V. ; Glorioso, N. / Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats. In: Hypertension. 1995 ; Vol. 25, No. 3. pp. 453-459.
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