Early bone marrow metastasis detection: The additional value of FDG-PET/CT vs. CT imaging

Laura Evangelista, Annalori Panunzio, Roberta Polverosi, Alice Ferretti, Sotirios Chondrogiannis, Fabio Pomerri, Domenico Rubello, Pier Carlo Muzzio

Research output: Contribution to journalArticle

Abstract

Objective: To assess the addition value of 18F-Fluorodeoxyglucose (FDG) PET/computed tomography (FDG-PET/CT) vs. CT in detecting early metastatic deposits in bone marrow (BM). Methods: From January 2009 to December 2010, 198 consecutive patients (88 male, 110 female; median age: 64 years) were retrospectively examined. All patients underwent 18F-FDG-PET/CT for disease evaluation: 65 for lung cancer, 66 for breast cancer, 57 for lymphoma and 10 for multiple myeloma. All scans were reviewed by a radiologist and a specialist in nuclear medicine for the identification of bone lesions. The presence of BM metastases was confirmed by biopsy, sequential PET/CT scan or magnetic resonance imaging when available. A patient-based analysis was performed. Results: Investigating the presence of skeletal metastasis, 94 (48%) patients had positive and 104 (52%) negative CT scan whereas 110 (56%) had positive and 88 (44%) negative FDG-PET/CT scan (. P

Original languageEnglish
Pages (from-to)448-453
Number of pages6
JournalBiomedicine and Pharmacotherapy
Volume66
Issue number6
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Bone marrow
  • CT scan
  • FDG-PET/CT
  • Lymphoma
  • Metastasis
  • Solid cancer

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Evangelista, L., Panunzio, A., Polverosi, R., Ferretti, A., Chondrogiannis, S., Pomerri, F., Rubello, D., & Muzzio, P. C. (2012). Early bone marrow metastasis detection: The additional value of FDG-PET/CT vs. CT imaging. Biomedicine and Pharmacotherapy, 66(6), 448-453. https://doi.org/10.1016/j.biopha.2012.06.004