Early but not lasting improvement of recalcitrant subcorneal pustular dermatosis (Sneddon-Wilkinson disease) after infliximab therapy: Relationships with variations in cytokine levels in suction blister fluids

Claudio Bonifati, E. Trento, P. Cordiali Fei, L. Muscardin, A. Amantea, M. Carducci

Research output: Contribution to journalArticlepeer-review

Abstract

Subcorneal pustular dermatosis (SCPD) is an uncommon disorder, characterized by a chronic relapsing vesiculopustular eruption, mainly involving the trunk and intertriginous areas, and usually seen in women > 40 years old. Various therapies have been reported to be effective in treating SCPD, such as dapsone, systemic glucocorticoids, acitretin, etretinate, infliximab and phototherapy. We report a case of a 54-year-old woman affected by SCPD who after failure of different therapies showed a dramatic but only temporary improvement of her disease during a cycle of therapy with infliximab. In addition, an array of cytokines was simultaneously measured in suction blister fluids obtained from involved or uninvolved skin at various time intervals during the first 12 weeks of observation.

Original languageEnglish
Pages (from-to)662-665
Number of pages4
JournalClinical and Experimental Dermatology
Volume30
Issue number6
DOIs
Publication statusPublished - Nov 2005

ASJC Scopus subject areas

  • Dermatology

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