Early carotid atherosclerosis in normotensive severe obese premenopausal women with low DHEA(S)

Silvia Savastano, R. Valentino, A. Belfiore, N. De Luca, A. De Alteriis, F. Orio, S. Palomba, A. M. Villani, C. Falcone, G. Lupoli, G. Lombardi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The aim of this study was to investigate the direct involvement of hyperinsulinaemia, DHEA and DHEA-S [DHEA(S)] in severe obesity in early carotid atherosclerosis, measured as intima-media thickness (IMT). Seventeen normotensive premenopausal women with very high BMI (43.5±1.6 kg/m2) were recruited for the study. Six women were also evaluated 12 months after laparoscopic adjustable silicone gastric banding (LASGB). Dietary intake, fasting plasma lipid profile, glycemic and insulinemic response to the OGTT, adrenal secretion, at baseline and after ACTH stimulation test, were measured. IMT, common carotid diameter (CD) and left ventricular mass index (LVMi) were measured by B-mode echotomography. All obese subjects showed higher fasting and stimulated insulin levels, but lower DHEA(S) levels than controls, showing a negative correlation between both fasting and stimulated insulin and DHEA(S), either at baseline or after ACTH testing. IMT was higher (p

Original languageEnglish
Pages (from-to)236-243
Number of pages8
JournalJournal of Endocrinological Investigation
Volume26
Issue number3
Publication statusPublished - Mar 2003

Fingerprint

Carotid Artery Diseases
Dehydroepiandrosterone
Fasting
Adrenocorticotropic Hormone
Insulin
Carotid Intima-Media Thickness
Morbid Obesity
Hyperinsulinism
Silicones
Glucose Tolerance Test
Ultrasonography
Stomach
Lipids

Keywords

  • Atherosclerosis
  • Cardiovascular risks
  • DHEA(S)
  • Hyperinsulinemia
  • Severe obesity

ASJC Scopus subject areas

  • Endocrinology

Cite this

Savastano, S., Valentino, R., Belfiore, A., De Luca, N., De Alteriis, A., Orio, F., ... Lombardi, G. (2003). Early carotid atherosclerosis in normotensive severe obese premenopausal women with low DHEA(S). Journal of Endocrinological Investigation, 26(3), 236-243.

Early carotid atherosclerosis in normotensive severe obese premenopausal women with low DHEA(S). / Savastano, Silvia; Valentino, R.; Belfiore, A.; De Luca, N.; De Alteriis, A.; Orio, F.; Palomba, S.; Villani, A. M.; Falcone, C.; Lupoli, G.; Lombardi, G.

In: Journal of Endocrinological Investigation, Vol. 26, No. 3, 03.2003, p. 236-243.

Research output: Contribution to journalArticle

Savastano, S, Valentino, R, Belfiore, A, De Luca, N, De Alteriis, A, Orio, F, Palomba, S, Villani, AM, Falcone, C, Lupoli, G & Lombardi, G 2003, 'Early carotid atherosclerosis in normotensive severe obese premenopausal women with low DHEA(S)', Journal of Endocrinological Investigation, vol. 26, no. 3, pp. 236-243.
Savastano S, Valentino R, Belfiore A, De Luca N, De Alteriis A, Orio F et al. Early carotid atherosclerosis in normotensive severe obese premenopausal women with low DHEA(S). Journal of Endocrinological Investigation. 2003 Mar;26(3):236-243.
Savastano, Silvia ; Valentino, R. ; Belfiore, A. ; De Luca, N. ; De Alteriis, A. ; Orio, F. ; Palomba, S. ; Villani, A. M. ; Falcone, C. ; Lupoli, G. ; Lombardi, G. / Early carotid atherosclerosis in normotensive severe obese premenopausal women with low DHEA(S). In: Journal of Endocrinological Investigation. 2003 ; Vol. 26, No. 3. pp. 236-243.
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