Die Nutzung frühe Veränderungen in Dichte und volumens der Ohrspeicheldrüse als Prädicator für Modifikationen am Ende der Therapie und der Intensität akuter Xerostomie

Translated title of the contribution: Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia

Maria Luisa Belli, Elisa Scalco, Giuseppe Sanguineti, Claudio Fiorino, Sara Broggi, Nicola Dinapoli, Francesco Ricchetti, Vincenzo Valentini, Giovanna Rizzo, Giovanni Mauro Cattaneo

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer.

Materials and methods: Data of 92 parotids (46 patients) were available. Kinetics of the changes during treatment were described by the daily rate of density (rΔρ) and volume (rΔvol) variation based on weekly diagnostic kVCT images. Correlation between early and final changes was investigated as well as the correlation with prospective toxicity data (CTCAEv3.0) collected weekly during treatment for 24/46 patients.

Results: A higher rΔρ was observed during the first compared to last week of treatment (−0,50 vs −0,05HU, p-value = 0.0001). Based on early variations, a good estimation of the final changes may be obtained (Δρ: AUC = 0.82, p = 0.0001; Δvol: AUC = 0.77, p = 0.0001).

Both early rΔρ and rΔvol predict a higher “mean” acute xerostomia score (≥ median value, 1.57; p-value = 0.01). Median early density rate changes for patients with mean xerostomia score ≥ / <1.57 were −0.98 vs −0.22 HU/day respectively (p = 0.05).

Conclusions: Early density and volume variations accurately predict final changes of parotid glands. A higher longitudinally assessed score of acute xerostomia is well predicted by higher rΔρ and rΔvol in the first two weeks of treatment: best cut-off values were −0.50 HU/day and −380 mm3/day for rΔρ and rΔvol respectively. Further studies are necessary to definitively assess the potential of early density/volume changes in identifying more sensitive patients at higher risk of experiencing xerostomia.

Translated title of the contributionEarly changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia
Original languageGerman
Pages (from-to)1001-1007
Number of pages7
JournalStrahlentherapie und Onkologie
Volume190
Issue number11
DOIs
Publication statusPublished - 2014

Keywords

  • Adaptive radiotherapy
  • Parotid deformation
  • Xerostomia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Medicine(all)

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