Early deaths in acute lymphoblastic leukemia (ALL): Results of the Italian pediatric cooperative group for therapy of acute leukemia (AIL‐AIEOP)

Giorgio Dini, Marida Bartolini, Luisa Massimo, Adriana Ceci, Guido Paolucci, Giovanni Calculli, Antonio Russo, Saverio Magro, Carlo Guazzelli, Bruno M. Cesana, Moncilio Jankovic, Fausta Massolo, Maria T. Di Tullio, Margherita Lo Curto, Antonietta Marchi, Pier Antonio Macchia, Franco Mandelli, Girolamo Digilio, Domenico Rosati, Antonio AcquavivaEnrico Madon, Roberto Miniero, Paolo Tamaro

Research output: Contribution to journalArticle

Abstract

In this retrospective multicentric study, we report on early deaths (ie, those that occurred during the first month of treatment) in a total of 943 newly diagnosed ALL pediatric patients registered from 1976 to 1981 at 21 centers of the AIL‐AIEOP. Objectives of this study were as follows: (1) to verify the incidence and the cause of early death in a wide population of children with ALL and (2) to elucidate factors associated with early death and therefore to identify “high‐risk” groups of patients. Out of the 943 ALL patients, 39 (4.1%) early deaths were registered. Main causes were infection, 20 patients (51.3%); hemorrhage, 11 patients (28.3%); uric acid nephropathy, 2 patients (5.1%); cardiac failure, 3 patients (7.6%); syndrome of inappropriate antidiuretic hormone secretion, 1 patient. Two patients died during the first week of unknown cause. Thirteen factors measured at diagnosis and possibly influencing the early death rate were analyzed. Using the chi‐square test, only three of these factors (age, mediastinum status, surface markers) appear to have any significant influence on the early death rate. We also tried to determine how therapy influences this process by analyzing variations in the early death rate, other factors being equal. Significant differences in the early death rates were encountered in AIEOP protocols using different induction regimens.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalMedical and Pediatric Oncology
Volume12
Issue number3
DOIs
Publication statusPublished - 1984

Fingerprint

Group Psychotherapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Pediatrics
Mortality
Inappropriate ADH Syndrome
Age Factors
Mediastinum
Uric Acid
Cause of Death
Heart Failure
Retrospective Studies
Hemorrhage
Incidence
Therapeutics
Infection

Keywords

  • acute lymphoblastic leukemia
  • childhood ALL
  • early death

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Early deaths in acute lymphoblastic leukemia (ALL) : Results of the Italian pediatric cooperative group for therapy of acute leukemia (AIL‐AIEOP). / Dini, Giorgio; Bartolini, Marida; Massimo, Luisa; Ceci, Adriana; Paolucci, Guido; Calculli, Giovanni; Russo, Antonio; Magro, Saverio; Guazzelli, Carlo; Cesana, Bruno M.; Jankovic, Moncilio; Massolo, Fausta; Di Tullio, Maria T.; Curto, Margherita Lo; Marchi, Antonietta; Macchia, Pier Antonio; Mandelli, Franco; Digilio, Girolamo; Rosati, Domenico; Acquaviva, Antonio; Madon, Enrico; Miniero, Roberto; Tamaro, Paolo.

In: Medical and Pediatric Oncology, Vol. 12, No. 3, 1984, p. 189-193.

Research output: Contribution to journalArticle

Dini, G, Bartolini, M, Massimo, L, Ceci, A, Paolucci, G, Calculli, G, Russo, A, Magro, S, Guazzelli, C, Cesana, BM, Jankovic, M, Massolo, F, Di Tullio, MT, Curto, ML, Marchi, A, Macchia, PA, Mandelli, F, Digilio, G, Rosati, D, Acquaviva, A, Madon, E, Miniero, R & Tamaro, P 1984, 'Early deaths in acute lymphoblastic leukemia (ALL): Results of the Italian pediatric cooperative group for therapy of acute leukemia (AIL‐AIEOP)', Medical and Pediatric Oncology, vol. 12, no. 3, pp. 189-193. https://doi.org/10.1002/mpo.2950120309
Dini, Giorgio ; Bartolini, Marida ; Massimo, Luisa ; Ceci, Adriana ; Paolucci, Guido ; Calculli, Giovanni ; Russo, Antonio ; Magro, Saverio ; Guazzelli, Carlo ; Cesana, Bruno M. ; Jankovic, Moncilio ; Massolo, Fausta ; Di Tullio, Maria T. ; Curto, Margherita Lo ; Marchi, Antonietta ; Macchia, Pier Antonio ; Mandelli, Franco ; Digilio, Girolamo ; Rosati, Domenico ; Acquaviva, Antonio ; Madon, Enrico ; Miniero, Roberto ; Tamaro, Paolo. / Early deaths in acute lymphoblastic leukemia (ALL) : Results of the Italian pediatric cooperative group for therapy of acute leukemia (AIL‐AIEOP). In: Medical and Pediatric Oncology. 1984 ; Vol. 12, No. 3. pp. 189-193.
@article{d6c1e4df33c74ae28d1a34ba3f7e3168,
title = "Early deaths in acute lymphoblastic leukemia (ALL): Results of the Italian pediatric cooperative group for therapy of acute leukemia (AIL‐AIEOP)",
abstract = "In this retrospective multicentric study, we report on early deaths (ie, those that occurred during the first month of treatment) in a total of 943 newly diagnosed ALL pediatric patients registered from 1976 to 1981 at 21 centers of the AIL‐AIEOP. Objectives of this study were as follows: (1) to verify the incidence and the cause of early death in a wide population of children with ALL and (2) to elucidate factors associated with early death and therefore to identify “high‐risk” groups of patients. Out of the 943 ALL patients, 39 (4.1{\%}) early deaths were registered. Main causes were infection, 20 patients (51.3{\%}); hemorrhage, 11 patients (28.3{\%}); uric acid nephropathy, 2 patients (5.1{\%}); cardiac failure, 3 patients (7.6{\%}); syndrome of inappropriate antidiuretic hormone secretion, 1 patient. Two patients died during the first week of unknown cause. Thirteen factors measured at diagnosis and possibly influencing the early death rate were analyzed. Using the chi‐square test, only three of these factors (age, mediastinum status, surface markers) appear to have any significant influence on the early death rate. We also tried to determine how therapy influences this process by analyzing variations in the early death rate, other factors being equal. Significant differences in the early death rates were encountered in AIEOP protocols using different induction regimens.",
keywords = "acute lymphoblastic leukemia, childhood ALL, early death",
author = "Giorgio Dini and Marida Bartolini and Luisa Massimo and Adriana Ceci and Guido Paolucci and Giovanni Calculli and Antonio Russo and Saverio Magro and Carlo Guazzelli and Cesana, {Bruno M.} and Moncilio Jankovic and Fausta Massolo and {Di Tullio}, {Maria T.} and Curto, {Margherita Lo} and Antonietta Marchi and Macchia, {Pier Antonio} and Franco Mandelli and Girolamo Digilio and Domenico Rosati and Antonio Acquaviva and Enrico Madon and Roberto Miniero and Paolo Tamaro",
year = "1984",
doi = "10.1002/mpo.2950120309",
language = "English",
volume = "12",
pages = "189--193",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Early deaths in acute lymphoblastic leukemia (ALL)

T2 - Results of the Italian pediatric cooperative group for therapy of acute leukemia (AIL‐AIEOP)

AU - Dini, Giorgio

AU - Bartolini, Marida

AU - Massimo, Luisa

AU - Ceci, Adriana

AU - Paolucci, Guido

AU - Calculli, Giovanni

AU - Russo, Antonio

AU - Magro, Saverio

AU - Guazzelli, Carlo

AU - Cesana, Bruno M.

AU - Jankovic, Moncilio

AU - Massolo, Fausta

AU - Di Tullio, Maria T.

AU - Curto, Margherita Lo

AU - Marchi, Antonietta

AU - Macchia, Pier Antonio

AU - Mandelli, Franco

AU - Digilio, Girolamo

AU - Rosati, Domenico

AU - Acquaviva, Antonio

AU - Madon, Enrico

AU - Miniero, Roberto

AU - Tamaro, Paolo

PY - 1984

Y1 - 1984

N2 - In this retrospective multicentric study, we report on early deaths (ie, those that occurred during the first month of treatment) in a total of 943 newly diagnosed ALL pediatric patients registered from 1976 to 1981 at 21 centers of the AIL‐AIEOP. Objectives of this study were as follows: (1) to verify the incidence and the cause of early death in a wide population of children with ALL and (2) to elucidate factors associated with early death and therefore to identify “high‐risk” groups of patients. Out of the 943 ALL patients, 39 (4.1%) early deaths were registered. Main causes were infection, 20 patients (51.3%); hemorrhage, 11 patients (28.3%); uric acid nephropathy, 2 patients (5.1%); cardiac failure, 3 patients (7.6%); syndrome of inappropriate antidiuretic hormone secretion, 1 patient. Two patients died during the first week of unknown cause. Thirteen factors measured at diagnosis and possibly influencing the early death rate were analyzed. Using the chi‐square test, only three of these factors (age, mediastinum status, surface markers) appear to have any significant influence on the early death rate. We also tried to determine how therapy influences this process by analyzing variations in the early death rate, other factors being equal. Significant differences in the early death rates were encountered in AIEOP protocols using different induction regimens.

AB - In this retrospective multicentric study, we report on early deaths (ie, those that occurred during the first month of treatment) in a total of 943 newly diagnosed ALL pediatric patients registered from 1976 to 1981 at 21 centers of the AIL‐AIEOP. Objectives of this study were as follows: (1) to verify the incidence and the cause of early death in a wide population of children with ALL and (2) to elucidate factors associated with early death and therefore to identify “high‐risk” groups of patients. Out of the 943 ALL patients, 39 (4.1%) early deaths were registered. Main causes were infection, 20 patients (51.3%); hemorrhage, 11 patients (28.3%); uric acid nephropathy, 2 patients (5.1%); cardiac failure, 3 patients (7.6%); syndrome of inappropriate antidiuretic hormone secretion, 1 patient. Two patients died during the first week of unknown cause. Thirteen factors measured at diagnosis and possibly influencing the early death rate were analyzed. Using the chi‐square test, only three of these factors (age, mediastinum status, surface markers) appear to have any significant influence on the early death rate. We also tried to determine how therapy influences this process by analyzing variations in the early death rate, other factors being equal. Significant differences in the early death rates were encountered in AIEOP protocols using different induction regimens.

KW - acute lymphoblastic leukemia

KW - childhood ALL

KW - early death

UR - http://www.scopus.com/inward/record.url?scp=0021260696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021260696&partnerID=8YFLogxK

U2 - 10.1002/mpo.2950120309

DO - 10.1002/mpo.2950120309

M3 - Article

C2 - 6587179

AN - SCOPUS:0021260696

VL - 12

SP - 189

EP - 193

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 3

ER -