Early deaths in children after BMT

A. Garaventa, F. Porta, R. Rondelli, G. Dini, G. Meloni, F. Bonetti, C. Uderzo, A. De Manzini, R. Miniero, F. Brutti, P. Colleselli, S. Bagnulo, N. Santoro, P. Paolucci

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Abstract

In order to determine the incidence and causes of death during the first 100 days after BMT (early deaths) in a pediatric population we have examined data reported in the AIEOP BMT Registry. Up to July 1990, data on 486 children who underwent allogeneic (180) or autologous (306) BMT were evaluable. The children had acute lymphoblastic leukemia (148 cases), acute non-lymphoblastic leukemia (127 cases), neuroblastoma (82 cases), chronic myelogenous leukemia (15 cases), aplastic anemia (nine cases), solid tumors, lymphoma, immunodeficiency or storage diseases. The overall survival is 55% for allogeneic HLA matched and 38% for autologous transplants at 5 years, 24% for HLA mismatched graft at 2 years. Out of the 486 children, 70 (14%) died during the first 100 days after BMT: 33/306 (11%) after autologous BMT, 24/150 (16%) after allogeneic matched BMT and 13/30 (43%) after mismatched BMT. Causes of early death were as follows: disease progression: 12 children (10/306 after autologous and 2/180 after allogeneic BMT); infection: 12 children (five after autologous and seven after allogeneic BMT); interstitial pneumonitis: 21 children (seven after autologous and 14 after allogeneic BMT); cardiac failure: five children (four after autologous BMT); veno-occlusive disease: eight children (three after autologous, five after allogeneic BMT); acute renal failure: three children (one after autologous and two after allogeneic BMT); multiple organ failure: two cases (one after autologous BMT); cerebral hemorrhage: three children (one after autologous BMT); hypertension: one child; acute GVHD: three children (12% of early deaths after allogeneic BMT).

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalBone Marrow Transplantation
Volume10
Issue number5
Publication statusPublished - 1992

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cause of Death
Multiple Organ Failure
Aplastic Anemia
Interstitial Lung Diseases
Autografts
Cerebral Hemorrhage
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Neuroblastoma
Acute Kidney Injury
Registries
Disease Progression
Lymphoma
Heart Failure
Pediatrics
Hypertension
Transplants
Incidence
Infection
Population

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Garaventa, A., Porta, F., Rondelli, R., Dini, G., Meloni, G., Bonetti, F., ... Paolucci, P. (1992). Early deaths in children after BMT. Bone Marrow Transplantation, 10(5), 419-423.

Early deaths in children after BMT. / Garaventa, A.; Porta, F.; Rondelli, R.; Dini, G.; Meloni, G.; Bonetti, F.; Uderzo, C.; De Manzini, A.; Miniero, R.; Brutti, F.; Colleselli, P.; Bagnulo, S.; Santoro, N.; Paolucci, P.

In: Bone Marrow Transplantation, Vol. 10, No. 5, 1992, p. 419-423.

Research output: Contribution to journalArticle

Garaventa, A, Porta, F, Rondelli, R, Dini, G, Meloni, G, Bonetti, F, Uderzo, C, De Manzini, A, Miniero, R, Brutti, F, Colleselli, P, Bagnulo, S, Santoro, N & Paolucci, P 1992, 'Early deaths in children after BMT', Bone Marrow Transplantation, vol. 10, no. 5, pp. 419-423.
Garaventa A, Porta F, Rondelli R, Dini G, Meloni G, Bonetti F et al. Early deaths in children after BMT. Bone Marrow Transplantation. 1992;10(5):419-423.
Garaventa, A. ; Porta, F. ; Rondelli, R. ; Dini, G. ; Meloni, G. ; Bonetti, F. ; Uderzo, C. ; De Manzini, A. ; Miniero, R. ; Brutti, F. ; Colleselli, P. ; Bagnulo, S. ; Santoro, N. ; Paolucci, P. / Early deaths in children after BMT. In: Bone Marrow Transplantation. 1992 ; Vol. 10, No. 5. pp. 419-423.
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AU - Garaventa, A.

AU - Porta, F.

AU - Rondelli, R.

AU - Dini, G.

AU - Meloni, G.

AU - Bonetti, F.

AU - Uderzo, C.

AU - De Manzini, A.

AU - Miniero, R.

AU - Brutti, F.

AU - Colleselli, P.

AU - Bagnulo, S.

AU - Santoro, N.

AU - Paolucci, P.

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N2 - In order to determine the incidence and causes of death during the first 100 days after BMT (early deaths) in a pediatric population we have examined data reported in the AIEOP BMT Registry. Up to July 1990, data on 486 children who underwent allogeneic (180) or autologous (306) BMT were evaluable. The children had acute lymphoblastic leukemia (148 cases), acute non-lymphoblastic leukemia (127 cases), neuroblastoma (82 cases), chronic myelogenous leukemia (15 cases), aplastic anemia (nine cases), solid tumors, lymphoma, immunodeficiency or storage diseases. The overall survival is 55% for allogeneic HLA matched and 38% for autologous transplants at 5 years, 24% for HLA mismatched graft at 2 years. Out of the 486 children, 70 (14%) died during the first 100 days after BMT: 33/306 (11%) after autologous BMT, 24/150 (16%) after allogeneic matched BMT and 13/30 (43%) after mismatched BMT. Causes of early death were as follows: disease progression: 12 children (10/306 after autologous and 2/180 after allogeneic BMT); infection: 12 children (five after autologous and seven after allogeneic BMT); interstitial pneumonitis: 21 children (seven after autologous and 14 after allogeneic BMT); cardiac failure: five children (four after autologous BMT); veno-occlusive disease: eight children (three after autologous, five after allogeneic BMT); acute renal failure: three children (one after autologous and two after allogeneic BMT); multiple organ failure: two cases (one after autologous BMT); cerebral hemorrhage: three children (one after autologous BMT); hypertension: one child; acute GVHD: three children (12% of early deaths after allogeneic BMT).

AB - In order to determine the incidence and causes of death during the first 100 days after BMT (early deaths) in a pediatric population we have examined data reported in the AIEOP BMT Registry. Up to July 1990, data on 486 children who underwent allogeneic (180) or autologous (306) BMT were evaluable. The children had acute lymphoblastic leukemia (148 cases), acute non-lymphoblastic leukemia (127 cases), neuroblastoma (82 cases), chronic myelogenous leukemia (15 cases), aplastic anemia (nine cases), solid tumors, lymphoma, immunodeficiency or storage diseases. The overall survival is 55% for allogeneic HLA matched and 38% for autologous transplants at 5 years, 24% for HLA mismatched graft at 2 years. Out of the 486 children, 70 (14%) died during the first 100 days after BMT: 33/306 (11%) after autologous BMT, 24/150 (16%) after allogeneic matched BMT and 13/30 (43%) after mismatched BMT. Causes of early death were as follows: disease progression: 12 children (10/306 after autologous and 2/180 after allogeneic BMT); infection: 12 children (five after autologous and seven after allogeneic BMT); interstitial pneumonitis: 21 children (seven after autologous and 14 after allogeneic BMT); cardiac failure: five children (four after autologous BMT); veno-occlusive disease: eight children (three after autologous, five after allogeneic BMT); acute renal failure: three children (one after autologous and two after allogeneic BMT); multiple organ failure: two cases (one after autologous BMT); cerebral hemorrhage: three children (one after autologous BMT); hypertension: one child; acute GVHD: three children (12% of early deaths after allogeneic BMT).

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