Abstract
Cardiotoxicity is a well-known adverse effect of various chemotherapeutic agents that can be monitored by echocardiography. A decrease of left ventricular ejection fraction (LVEF) during the therapy might indicate dangerous effects of the drug on the myocardium and triggers consideration of therapy modification or interruption. We hypothesized myocardial deformation could identify preclinical myocardial dysfunction earlier than conventional LVEF allowing the administration of treatments to avoid cardiac side-effects. Sixty-five patients who were newly diagnosed with breast cancer, were enrolled to be evaluated by echocardiography before cancer therapy, during the therapy at 16 weeks (16w) and at follow up after 32 weeks (32w). Following the recommendation, 24 patients (36.9%) showed cardiotoxicity; 11 (16.9%) interrupted the therapy due to a severe cardiac dysfunction and at 32w only 4 patients recovered. In this group at 16w, strain analysis showed a significant reduction for all strain values that were all predictive of cardiotoxicity independently from LVEF and radial strain resulted an independent prognostic index of cardiotoxicity. The assessment of myocardial deformation indexes might provide additional echocardiographic tools to assess cardio-toxic effects beyond LVEF.
Original language | English |
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Title of host publication | Computing in Cardiology |
Pages | 249-252 |
Number of pages | 4 |
Volume | 40 |
Publication status | Published - 2013 |
Event | 2013 40th Computing in Cardiology Conference, CinC 2013 - Zaragoza, Spain Duration: Sep 22 2013 → Sep 25 2013 |
Other
Other | 2013 40th Computing in Cardiology Conference, CinC 2013 |
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Country/Territory | Spain |
City | Zaragoza |
Period | 9/22/13 → 9/25/13 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Computer Science(all)