Early detection of cardiotoxicity in chemotherapy-treated patients from real-time 3D echocardiography

Cinzia Lorenzini, Cristiana Corsi, Michele Aquilina, Andrea Casadei Gardini, Andrea Rocca, Luca Frassineti, Emanuela Scarpi, Dino Amadori, Claudio Lamberti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiotoxicity is a well-known adverse effect of various chemotherapeutic agents that can be monitored by echocardiography. A decrease of left ventricular ejection fraction (LVEF) during the therapy might indicate dangerous effects of the drug on the myocardium and triggers consideration of therapy modification or interruption. We hypothesized myocardial deformation could identify preclinical myocardial dysfunction earlier than conventional LVEF allowing the administration of treatments to avoid cardiac side-effects. Sixty-five patients who were newly diagnosed with breast cancer, were enrolled to be evaluated by echocardiography before cancer therapy, during the therapy at 16 weeks (16w) and at follow up after 32 weeks (32w). Following the recommendation, 24 patients (36.9%) showed cardiotoxicity; 11 (16.9%) interrupted the therapy due to a severe cardiac dysfunction and at 32w only 4 patients recovered. In this group at 16w, strain analysis showed a significant reduction for all strain values that were all predictive of cardiotoxicity independently from LVEF and radial strain resulted an independent prognostic index of cardiotoxicity. The assessment of myocardial deformation indexes might provide additional echocardiographic tools to assess cardio-toxic effects beyond LVEF.

Original languageEnglish
Title of host publicationComputing in Cardiology
Pages249-252
Number of pages4
Volume40
Publication statusPublished - 2013
Event2013 40th Computing in Cardiology Conference, CinC 2013 - Zaragoza, Spain
Duration: Sep 22 2013Sep 25 2013

Other

Other2013 40th Computing in Cardiology Conference, CinC 2013
CountrySpain
CityZaragoza
Period9/22/139/25/13

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Computer Science(all)

Cite this

Lorenzini, C., Corsi, C., Aquilina, M., Casadei Gardini, A., Rocca, A., Frassineti, L., Scarpi, E., Amadori, D., & Lamberti, C. (2013). Early detection of cardiotoxicity in chemotherapy-treated patients from real-time 3D echocardiography. In Computing in Cardiology (Vol. 40, pp. 249-252). [6712458]