Abstract
PURPOSE. To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS. A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 ± 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 18° of visual field. RESULTS. Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and-in 50% of the cases-fERG loss anticipated acuity loss of several years. CONCLUSIONS. Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.
| Original language | English |
|---|---|
| Pages (from-to) | 6560-6569 |
| Number of pages | 10 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 54 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- Cone-rod dystrophy
- Focal ERG
- Visual acuity
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Early detection of central visual function decline in cone-rod dystrophy by the use of macular focal cone electroretinogram. / Galli-Resta, Lucia; Piccardi, Marco; Ziccardi, Lucia; Fadda, Antonello; Minnella, Angelo; Marangoni, Dario; Placidi, Giorgio; Resta, Giovanni; Falsini, Benedetto.
In: Investigative Ophthalmology and Visual Science, Vol. 54, No. 10, 2013, p. 6560-6569.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early detection of central visual function decline in cone-rod dystrophy by the use of macular focal cone electroretinogram
AU - Galli-Resta, Lucia
AU - Piccardi, Marco
AU - Ziccardi, Lucia
AU - Fadda, Antonello
AU - Minnella, Angelo
AU - Marangoni, Dario
AU - Placidi, Giorgio
AU - Resta, Giovanni
AU - Falsini, Benedetto
PY - 2013
Y1 - 2013
N2 - PURPOSE. To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS. A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 ± 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 18° of visual field. RESULTS. Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and-in 50% of the cases-fERG loss anticipated acuity loss of several years. CONCLUSIONS. Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.
AB - PURPOSE. To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS. A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 ± 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 18° of visual field. RESULTS. Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and-in 50% of the cases-fERG loss anticipated acuity loss of several years. CONCLUSIONS. Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.
KW - Cone-rod dystrophy
KW - Focal ERG
KW - Visual acuity
UR - http://www.scopus.com/inward/record.url?scp=84885216188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885216188&partnerID=8YFLogxK
U2 - 10.1167/iovs.13-12676
DO - 10.1167/iovs.13-12676
M3 - Article
C2 - 24008410
AN - SCOPUS:84885216188
VL - 54
SP - 6560
EP - 6569
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 10
ER -