Early detection of deep vein thrombosis in patients with coronavirus disease 2019: who to screen and who not to with Doppler ultrasound?

Anna Maria Ierardi, Andrea Coppola, Stefano Fusco, Elvira Stellato, Stefano Aliberti, Maria Carmela Andrisani, Valentina Vespro, Antonio Arrichiello, Mauro Panigada, Valter Monzani, Giacomo Grasselli, Massimo Venturini, Bhavya Rehani, Flora Peyvandi, Antonio Pesenti, Francesco Blasi, Gianpaolo Carrafiello

Research output: Contribution to journalArticlepeer-review


Purpose: Aim of the study is to evaluate the incidence of DVT in COVID-19 patients and its correlation with the severity of the disease and with clinical and laboratory findings. Methods: 234 symptomatic patients with COVID-19, diagnosed according to the World Health Organization guidelines, were included in the study. The severity of the disease was classified as moderate, severe and critical. Doppler ultrasound (DUS) was performed in all patients. DUS findings, clinical, laboratory’s and therapeutic variables were investigated by contingency tables, Pearson chi square test and by Student t test and Fisher's exact test. ROC curve analysis was applied to study significant continuous variables. Results: Overall incidence of DVT was 10.7% (25/234): 1.6% (1/60) among moderate cases, 13.8% (24/174) in severely and critically ill patients. Prolonged bedrest and intensive care unit admission were significantly associated with the presence of DVT (19.7%). Fraction of inspired oxygen, P/F ratio, respiratory rate, heparin administration, D-dimer, IL-6, ferritin and CRP showed correlation with DVT. Conclusion: DUS may be considered a useful and valid tool for early identification of DVT. In less severely affected patients, DUS as screening of DVT might be unnecessary. High rate of DVT found in severe patients and its correlation with respiratory parameters and some significant laboratory findings suggests that these can be used as a screening tool for patients who should be getting DUS.

Original languageEnglish
Pages (from-to)165-173
JournalJournal of Ultrasound
Issue number2
Publication statusPublished - 2021


  • COVID-19
  • Doppler; diagnosis
  • Pandemics
  • Ultrasonography
  • Venous thrombosis

ASJC Scopus subject areas

  • Internal Medicine
  • Radiology Nuclear Medicine and imaging


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