Early DEtection of wEaring off in Parkinson disease: The DEEP study

F. Stocchi, A. Antonini, P. Barone, M. Tinazzi, M. Zappia, M. Onofrj, S. Ruggieri, L. Morgante, U. Bonuccelli, L. Lopiano, P. Pramstaller, A. Albanese, M. Attar, V. Posocco, D. Colombo, G. Abbruzzese

Research output: Contribution to journalArticlepeer-review


Objective: Assessing the frequency of Wearing-Off (WO) in Parkinson's disease (PD) patients, and its impact on Quality of Life (QoL). Methods: Consecutive ambulatory patients, who were on dopaminergic treatment for ≥1 year, were included in this multicentre, observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as using the validated Italian version of a patient self-rated 19-question Wearing-Off Questionnaire (WOQ-19); WO was defined for scores≥2. QoL was evaluated by the 8-item Parkinson's Disease Questionnaire (PDQ-8). Results: 617 subjects were included, with a mean anti-Parkinson treatment duration of 6.6±4.6 years, 87.2% were on levodopa treatment. Neurologists identified presence of WO in 351 subjects (56.9%), whereas 415 subjects (67.3%) were identified by the self-administered WOQ-19. In patients with a

Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalParkinsonism and Related Disorders
Issue number2
Publication statusPublished - Feb 2014


  • Parkinson's disease
  • Quality of life
  • Wearing-off
  • Wearing-off questionnaire

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology


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