TY - JOUR
T1 - Early development of epileptic infants with pre- or perinatal brain injuries
T2 - Role of the epileptic disorder
AU - Barone, M. R.
AU - Battaglia, D.
AU - Veredice, C.
AU - De Waure, C.
AU - Ricci, D.
AU - Baranello, G.
AU - Mercuri, E.
AU - Guzzetta, F.
PY - 2009
Y1 - 2009
N2 - To try to understand the causative role of epilepsy per se in the developmental deterioration of brain injured infants, twenty-eight infants affected with early acquired, pre- and perinatal brain injuries were enrolled and divided into three groups, a) those with West syndrome, b) those with other non-West epilepsies, and c) those without epilepsy. Developmental monitoring consisted of a full clinical assessment, including examination of visual function, Griffiths developmental scales, standard EEG, long-term monitoring when necessary, and MRI, from the seizure onset or the first observation to the end of follow-up. Patients with epilepsy showed at study onset abnormal clinical features (neurological and developmental) distinct from those of non-epileptic patients, partially due to the varying severity of their brain injuries. A definite differentiation between groups was observed in the clinical evolution that showed among the epileptic patients, mostly in West syndrome, a significant deterioration. Moreover, impaired visual function at seizure onset was possibly associated with a bad developmental evolution. A developmental deterioration, mostly in West syndrome, accounts for a causative role of the epileptic disorder per se, but in few cases it was also observed in infants with only a brain injury, suggesting other aetiopathogenic mechanisms. The predictive value of early visual function seems to be confirmed.
AB - To try to understand the causative role of epilepsy per se in the developmental deterioration of brain injured infants, twenty-eight infants affected with early acquired, pre- and perinatal brain injuries were enrolled and divided into three groups, a) those with West syndrome, b) those with other non-West epilepsies, and c) those without epilepsy. Developmental monitoring consisted of a full clinical assessment, including examination of visual function, Griffiths developmental scales, standard EEG, long-term monitoring when necessary, and MRI, from the seizure onset or the first observation to the end of follow-up. Patients with epilepsy showed at study onset abnormal clinical features (neurological and developmental) distinct from those of non-epileptic patients, partially due to the varying severity of their brain injuries. A definite differentiation between groups was observed in the clinical evolution that showed among the epileptic patients, mostly in West syndrome, a significant deterioration. Moreover, impaired visual function at seizure onset was possibly associated with a bad developmental evolution. A developmental deterioration, mostly in West syndrome, accounts for a causative role of the epileptic disorder per se, but in few cases it was also observed in infants with only a brain injury, suggesting other aetiopathogenic mechanisms. The predictive value of early visual function seems to be confirmed.
KW - brain-injured infants
KW - early development
KW - early onset symptomatic epilepsy
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U2 - 10.1055/s-0030-1248248
DO - 10.1055/s-0030-1248248
M3 - Article
C2 - 20221957
AN - SCOPUS:77953386230
VL - 40
SP - 218
EP - 223
JO - Neuropediatrics
JF - Neuropediatrics
SN - 0174-304X
IS - 5
ER -