Early development of the Drosophila mushroom bodies, brain centres for associative learning and memory

Marco Tettamanti, J. Douglas Armstrong, Keita Endo, Ming Yao Yang, Katsuo Furukubo-Tokunaga, Kim Kaiser, Heinrich Reichert

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied the formation of Drosophila mushroom bodies using enhancer detector techniques to visualize specific components of these complex intrinsic brain structures. During embryogenesis, neuronal proliferation begins in four mushroom body neuroblasts and the major axonal pathways of the mushroom bodies are pioneered. During larval development, neuronal proliferation continues and further axonal projections in the pedunculus and lobes are formed in a highly structured manner characterized by spatial heterogeneity of reporter gene expression. Enhancer detector analysis identifies many genomic locations that are specifically activated in mushroom body intrinsic neurons (Kenyon cells) during the transition from embryonic to postembryonic development and during metamorphosis.

Original languageEnglish
Pages (from-to)242-252
Number of pages11
JournalDevelopment Genes and Evolution
Volume207
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Drosophila
  • Enhancer-trap
  • GAL4
  • Kenyon cells
  • Mushroom bodies

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Cell Biology
  • Developmental Biology
  • Genetics

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