We describe a 57 year-old man who developed progressive symmetric weakness affecting the legs. At that time no sensory or autonomie symptoms were present. NCS and thermography were normal. Motor nerve biopsy of the obturator nerve, was performed and showed by Congo Red staining amyloid deposits infiltrating endoneurial blood) vessel walls, reduction of myelinated fibers and signs of active axonal degeneration. At follow up after six months the patient complained of distal sensory symptoms as pain and loss of felling and autonomie symptoms. At that time the presence of a plasma cells dyscrasia with a serum monoclonal protein IgG lambda was found. The amyloid neuropathy with motor onset should be considered and investigated in the differential diagnosis of Lower Motor Neuron Disease.
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology