TY - JOUR
T1 - Early diagnosis of malignant melanoma
T2 - Proposal of a working formulation for the management of cutaneous pigmented lesions from the Melanoma Cooperative Group.
AU - Ascierto, Paolo A.
AU - Palmieri, Giuseppe
AU - Botti, Gerardo
AU - Satriano, Rocco A.
AU - Stanganelli, Ignazio
AU - Bono, Riccardo
AU - Testori, Alessandro
AU - Bosco, Leonardo
AU - Daponte, Antonio
AU - Caracò, Corrado
AU - Chiofalo, Maria Grazia
AU - Melucci, Maria Teresa
AU - Calignano, Rosario
AU - Tatangelo, Fabiana
AU - Cochran, Alistair J.
AU - Castello, Giuseppe
PY - 2003/6
Y1 - 2003/6
N2 - Epiluminescence microscopy (ELM) strongly improves the separation of different types of cutaneous pigmented lesions (CPL) and facilitates the early diagnosis of cutaneous melanoma (CM). ELM alone is not 100% accurate in routine diagnosis, and should not be considered the only criterion in the diagnosis of high-risk skin lesions. We have however, demonstrated close agreement between ELM classification criteria and histology in 2,731 cutaneous lesions. In the past five years, our Melanoma Cooperative Group has evaluated 61,000 skin lesions from 30,000 individuals and identified 478 cutaneous melanomas. Most newly diagnosed patients had very early stage melanoma [299 (62%) were Stage I (203 Stage IA and 96 Stage IB), by the American Joint Committee on Cancer (AJCC) criteria]. We have compared data from the patient histories and clinical evaluations with ELM-based morphological patterns to better characterize skin lesions and minimize interpretative problems. From these comparisons, we propose new guidelines for the management of CPL to provide a standard diagnostic and therapeutic approaches and to foster the early identification of lesions at risk for malignant transformation.
AB - Epiluminescence microscopy (ELM) strongly improves the separation of different types of cutaneous pigmented lesions (CPL) and facilitates the early diagnosis of cutaneous melanoma (CM). ELM alone is not 100% accurate in routine diagnosis, and should not be considered the only criterion in the diagnosis of high-risk skin lesions. We have however, demonstrated close agreement between ELM classification criteria and histology in 2,731 cutaneous lesions. In the past five years, our Melanoma Cooperative Group has evaluated 61,000 skin lesions from 30,000 individuals and identified 478 cutaneous melanomas. Most newly diagnosed patients had very early stage melanoma [299 (62%) were Stage I (203 Stage IA and 96 Stage IB), by the American Joint Committee on Cancer (AJCC) criteria]. We have compared data from the patient histories and clinical evaluations with ELM-based morphological patterns to better characterize skin lesions and minimize interpretative problems. From these comparisons, we propose new guidelines for the management of CPL to provide a standard diagnostic and therapeutic approaches and to foster the early identification of lesions at risk for malignant transformation.
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M3 - Article
C2 - 12738985
AN - SCOPUS:0041627369
VL - 22
SP - 1209
EP - 1215
JO - International Journal of Oncology
JF - International Journal of Oncology
SN - 1019-6439
IS - 6
ER -