Early effects comparison of X rays delivered at high-dose-rate pulses by a plasma focus device and at low dose rate on human tumour cells

A. Virelli, I. Zironi, F. Pasi, E. Ceccolini, R. Nano, A. Facoetti, E. Gavoçi, M. R. Fiore, F. Rocchi, D. Mostacci, G. Cucchi, G. Castellani, M. Sumini, R. Orecchia

Research output: Contribution to journalArticlepeer-review

Abstract

A comparative study has been performed on the effects of high-dose-rate (DR) X-ray beams produced by a plasma focus device (PFMA-3), to exploit its potential medical applications (e.g. radiotherapy), and low-DR X-ray beams produced by a conventional source (XRT). Experiments have been performed at 0.5 and 2 Gy doses on a human glioblastoma cell line (T98G). Cell proliferation rate and potassium outward currents (IK) have been investigated by time lapse imaging and patch clamp recordings. The results showed that PFMA-3 irradiation has a greater capability to reduce the proliferation rate activity with respect to XRT, while it does not affect IK of T98G cells at any of the dose levels tested. XRT irradiation significantly reduces the mean IK amplitude of T98G cells only at 0.5 Gy. This work confirms that the DR, and therefore the source of radiation, is crucial for the planning and optimisation of radiotherapy applications.

Original languageEnglish
Article numberncv163
Pages (from-to)383-387
Number of pages5
JournalRadiation Protection Dosimetry
Volume166
Issue number1-4
DOIs
Publication statusPublished - Sep 1 2015

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation
  • Public Health, Environmental and Occupational Health

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