Early effects of GM1 in experimental cerebral focal ischemia in rabbits.

P. Bo, E. Marchioni, D. Soragna, F. Savoldi

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This study aimed to investigate the effects of monosialoganglioside (GM1) when administered early in a model of cerebral focal ischemia, in the rabbit. The statistical evaluation of the electroencephalographic changes (quantified EEG analysis, QEEG) due to the ischemic event showed that the early treatment (1-3-24 h) with GM1 reduced the EEgraphic pattern typical of this model of cerebral ischemia. Considering the observation period, we hypothesized that it was due to the formation of an oedema of a lesser degree compared to the untreated group. Particularly, we did not obtain the increase in delta activity on the contralateral hemisphere, which we thought was expression of the diaschisi phenomenon.

Original languageEnglish
Pages (from-to)705-710
Number of pages6
JournalBollettino della Societa Italiana di Biologia Sperimentale
Issue number11
Publication statusPublished - Nov 1993

ASJC Scopus subject areas

  • Medicine(all)

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