Early effects of total paracentesis and albumin infusion on muscle sympathetic nerve activity in cirrhotic patients with tense ascites

Massimo Pozzi, Guido Grassi, Valeria Pecci, Carlo Turri, Giuseppe Boari, Giovanni Battista Bolla, Raffaella Dell'Oro, Sara Massironi, Luigi Roffi, Giuseppe Mancia

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Aims: Cirrhotic patients with ascites are characterized by a marked activation of the sympathetic and the renin-angiotensin-aldosterone system. Total paracentesis is associated with a short-lived suppression of the renin-angiotensin-aldosterone system. Little information exists as to whether this favourable effect is parallelled by sympathoinhibition. Methods: In 16 Child C cirrhotic patients (age: 57.1±6.2 years, mean±SEM) with tense ascites we assessed the time course of the effects of total paracentesis followed by intravenous albumin (6-8 g/l of ascites) on beat-to-beat mean arterial pressure (Finapres), heart rate, plasma norepinephrine, epinephrine (high performance liquid chromatography) and muscle sympathetic nerve activity (microneurography, peroheal nerve). Measurements were obtained under baseline conditions, during staged removal of ascitic fluid (250 ml/min) and 24 h later. The patient remained supine throughout the study period. Results: Total paracentesis (10.6±1.3 l) induced a decrease in mean arterial pressure (from 95.0±2.6 mmHg to 88.2±3.2 mmHg, p

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalJournal of Hepatology
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 1999

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Paracentesis
Ascites
Albumins
Renin-Angiotensin System
Muscles
Arterial Pressure
Ascitic Fluid
Epinephrine
Norepinephrine
Heart Rate
High Pressure Liquid Chromatography

Keywords

  • Arterial baroreflexes
  • Catecholamines
  • Renin angiotensin aldosterone system
  • Sympathetic nervous system
  • Total paracentesis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Early effects of total paracentesis and albumin infusion on muscle sympathetic nerve activity in cirrhotic patients with tense ascites. / Pozzi, Massimo; Grassi, Guido; Pecci, Valeria; Turri, Carlo; Boari, Giuseppe; Bolla, Giovanni Battista; Dell'Oro, Raffaella; Massironi, Sara; Roffi, Luigi; Mancia, Giuseppe.

In: Journal of Hepatology, Vol. 30, No. 1, 01.1999, p. 95-100.

Research output: Contribution to journalArticle

Pozzi, Massimo ; Grassi, Guido ; Pecci, Valeria ; Turri, Carlo ; Boari, Giuseppe ; Bolla, Giovanni Battista ; Dell'Oro, Raffaella ; Massironi, Sara ; Roffi, Luigi ; Mancia, Giuseppe. / Early effects of total paracentesis and albumin infusion on muscle sympathetic nerve activity in cirrhotic patients with tense ascites. In: Journal of Hepatology. 1999 ; Vol. 30, No. 1. pp. 95-100.
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AU - Bolla, Giovanni Battista

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