Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis: A randomized clinical trial

D. Radrizzani, G. Bertolini, R. Facchini, B. Simini, P. Bruzzone, G. Zanforlin, G. Tognoni, G. Iapichino

Research output: Contribution to journalArticle

Abstract

Objectives: We compared early parenteral nutrition (PN) and early enteral immunonutrition (iEN) in critically ill patients, distinguishing those with and without severe sepsis or septic shock (SS) on admission to intensive care units (ICUs). Design and setting: Multicenter, randomized, unblinded clinical trial in 33 Italian general ICUs. Patients and participants: The study included 326 patients, 287 of whom did not have SS on ICU admission. Eligibility criteria excluded the two tails in the spectrum of critical conditions, i.e., patients either too well or too ill. Of the patients recruited 160 were randomized to iEN (142 without SS) and 166 to PN (145 without SS). Interventions: Patients were randomized to two arms: early iEN or early PN. Measurements and results: Primary endpoint was 28-day mortality for all patients and the occurrence of SS during ICU stay for patients admitted without such condition. While 28-day mortality did not differ between iEN and PN (15.6% vs. 15.1%), patients without SS who received iEN had fewer episodes of severe sepsis or septic shock (4.9% vs. 13.1%). ICU length of stay was 4 days shorter in patients given iEN. Conclusions: Compared to parenteral nutrition iEN appears to be beneficial in critical patients without severe sepsis or septic shock. Parenteral nutrition in these patients should be abandoned, at least when enteral nutrition can be administered, even at an initial low caloric content.

Original languageEnglish
Pages (from-to)1191-1198
Number of pages8
JournalIntensive Care Medicine
Volume32
Issue number8
DOIs
Publication statusPublished - Aug 2006

Fingerprint

Parenteral Nutrition
Critical Illness
Small Intestine
Sepsis
Randomized Controlled Trials
Septic Shock
Intensive Care Units
Mortality
Enteral Nutrition
Length of Stay

Keywords

  • Critical illness
  • Enteral nutrition
  • Immunonutrition
  • Parenteral nutrition
  • Pneumonia
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis : A randomized clinical trial. / Radrizzani, D.; Bertolini, G.; Facchini, R.; Simini, B.; Bruzzone, P.; Zanforlin, G.; Tognoni, G.; Iapichino, G.

In: Intensive Care Medicine, Vol. 32, No. 8, 08.2006, p. 1191-1198.

Research output: Contribution to journalArticle

Radrizzani, D. ; Bertolini, G. ; Facchini, R. ; Simini, B. ; Bruzzone, P. ; Zanforlin, G. ; Tognoni, G. ; Iapichino, G. / Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis : A randomized clinical trial. In: Intensive Care Medicine. 2006 ; Vol. 32, No. 8. pp. 1191-1198.
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AU - Simini, B.

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AU - Tognoni, G.

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