Abstract
Human serum contains a thymus-dependent factor that raises cyclic AMP levels in thymocytes. We found that this factor stimulates protein synthesis in thymocytes cultured in vitro. This activity of serum factor is thymus-dependent, because it is absent in sera from thymectomized donors; furthermore, this effect is predominantly found on precursors of mature T cells. Incubation of thymocytes with other agents that increase cyclic AMP, induces an increase in protein synthesis similar to that observed with serum factor. Most likely, the increase in protein synthesis is one of the events following stimulation of adenylate cyclase in thymocytes that leads to cell differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 88-96 |
| Number of pages | 9 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 86 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 15 1979 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Early events in thymocyte activation. I. Stimulation of protein synthesis by a thymus-dependent human serum factor. / Wijermans, P.; Astaldi, G. C B; Facchini, A.; Schellekens, P. Th A; Astaldi, A.
In: Biochemical and Biophysical Research Communications, Vol. 86, No. 1, 15.01.1979, p. 88-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early events in thymocyte activation. I. Stimulation of protein synthesis by a thymus-dependent human serum factor
AU - Wijermans, P.
AU - Astaldi, G. C B
AU - Facchini, A.
AU - Schellekens, P. Th A
AU - Astaldi, A.
PY - 1979/1/15
Y1 - 1979/1/15
N2 - Human serum contains a thymus-dependent factor that raises cyclic AMP levels in thymocytes. We found that this factor stimulates protein synthesis in thymocytes cultured in vitro. This activity of serum factor is thymus-dependent, because it is absent in sera from thymectomized donors; furthermore, this effect is predominantly found on precursors of mature T cells. Incubation of thymocytes with other agents that increase cyclic AMP, induces an increase in protein synthesis similar to that observed with serum factor. Most likely, the increase in protein synthesis is one of the events following stimulation of adenylate cyclase in thymocytes that leads to cell differentiation.
AB - Human serum contains a thymus-dependent factor that raises cyclic AMP levels in thymocytes. We found that this factor stimulates protein synthesis in thymocytes cultured in vitro. This activity of serum factor is thymus-dependent, because it is absent in sera from thymectomized donors; furthermore, this effect is predominantly found on precursors of mature T cells. Incubation of thymocytes with other agents that increase cyclic AMP, induces an increase in protein synthesis similar to that observed with serum factor. Most likely, the increase in protein synthesis is one of the events following stimulation of adenylate cyclase in thymocytes that leads to cell differentiation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018317638&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(79)90385-1
DO - 10.1016/0006-291X(79)90385-1
M3 - Article
C2 - 219856
AN - SCOPUS:0018317638
VL - 86
SP - 88
EP - 96
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -