Early events in thymocyte activation. I. Stimulation of protein synthesis by a thymus-dependent human serum factor

P. Wijermans, G. C B Astaldi, A. Facchini, P. Th A Schellekens, A. Astaldi

Research output: Contribution to journalArticle

Abstract

Human serum contains a thymus-dependent factor that raises cyclic AMP levels in thymocytes. We found that this factor stimulates protein synthesis in thymocytes cultured in vitro. This activity of serum factor is thymus-dependent, because it is absent in sera from thymectomized donors; furthermore, this effect is predominantly found on precursors of mature T cells. Incubation of thymocytes with other agents that increase cyclic AMP, induces an increase in protein synthesis similar to that observed with serum factor. Most likely, the increase in protein synthesis is one of the events following stimulation of adenylate cyclase in thymocytes that leads to cell differentiation.

Original languageEnglish
Pages (from-to)88-96
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume86
Issue number1
DOIs
Publication statusPublished - Jan 15 1979

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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