Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis

G. Celesti, G. Di Caro, P. Bianchi, F. Grizzi, F. Marchesi, G. Basso, D. Rahal, G. Delconte, M. Catalano, P. Cappello, M. Roncalli, A. Zerbi, M. Montorsi, F. Novelli, A. Mantovani, P. Allavena, A. Malesci, L. Laghi

Research output: Contribution to journalArticlepeer-review

Abstract

Background:In pancreatic ductal adenocarcinoma (PDAC), fractalkine receptor CX3CR1 contributes to perineural invasion (PNI). We investigated whether CX3CR1 expression occurs early in PDAC and correlates with tumour features other than PNI.Methods:We studied CX3CR1 and CX3CL1 expression by immunohistochemistry in 104 human PDAC and coexisting Pancreatic Intraepithelial Neoplasia (PanIN), and in PdxCre/LSL-Kras G12D mouse model of PDAC. CX3CR1 expression in vitro was studied by a spheroid model, and in vivo by syngenic mouse graft of tumour cells.Results:In total, 56 (53.9%) PDAC expressed CX3CR1, 70 (67.3%) CX3CL1, and 45 (43.3%) both. CX3CR1 expression was independently associated with tumour glandular differentiation (P=0.005) and PNI (P=0.01). Pancreatic Intraepithelial Neoplasias were more frequently CX3CR1+ (80.3%, P

Original languageEnglish
Pages (from-to)2424-2433
Number of pages10
JournalBritish Journal of Cancer
Volume109
Issue number9
DOIs
Publication statusPublished - Oct 29 2013

Keywords

  • chemokines and chemokine receptors
  • pancreatic cancer
  • pancreatic intraepithelial neoplasia (PanIN)
  • tumour differentiation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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