TY - JOUR
T1 - Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke
AU - Zangari, R.
AU - Roncati Zanier, Elisa
AU - Torgano, Giuseppe Gaudenzio
AU - Bersano, Anna
AU - Beretta, Simone
AU - Beghi, Ettore
AU - Casolla, B.
AU - Checcarelli, N.
AU - Lanfranconi, Silvia
AU - Maino, Alberto
AU - Mandelli, C.
AU - Micieli, Giuseppe
AU - Orzi, Francesco
AU - Picetti, Edoardo
AU - Silvestrini, Mauro
AU - Stocchetti, Nino
AU - Zecca, B.
AU - Garred, Peter
AU - De Simoni, Maria Grazia
PY - 2016
Y1 - 2016
N2 - Background: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke. Methods: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS). Results: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p <0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p <0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p <0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p <0.001 and
AB - Background: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke. Methods: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS). Results: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p <0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p <0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p <0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p <0.001 and
KW - Ficolin-1
KW - Ficolin-2
KW - Ficolin-3
KW - Innate immunity
KW - Ischemic stroke
KW - Lectin pathway
KW - MBL
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U2 - 10.1186/s12974-016-0481-2
DO - 10.1186/s12974-016-0481-2
M3 - Article
VL - 13
JO - Journal of Neuroinflammation
JF - Journal of Neuroinflammation
SN - 1742-2094
IS - 1
M1 - 16
ER -