Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke

R. Zangari; Elisa Roncati Zanier; Giuseppe Gaudenzio Torgano; Anna Bersano; Simone Beretta; Ettore Beghi; B. Casolla; N. Checcarelli; Silvia Lanfranconi; Alberto Maino; C. Mandelli; Giuseppe Micieli; Francesco Orzi; Edoardo Picetti; Mauro Silvestrini; Nino Stocchetti; B. Zecca; Peter Garred; Maria Grazia De Simoni

doi:10.1186/s12974-016-0481-2

Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke

R. Zangari, Elisa Roncati Zanier, Giuseppe Gaudenzio Torgano, Anna Bersano, Simone Beretta, Ettore Beghi, B. Casolla, N. Checcarelli, Silvia Lanfranconi, Alberto Maino, C. Mandelli, Giuseppe Micieli, Francesco Orzi, Edoardo Picetti, Mauro Silvestrini, Nino Stocchetti, B. Zecca, Peter Garred, Maria Grazia De Simoni

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke. Methods: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS). Results: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p <0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p <0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p <0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p <0.001 and

Original language	English
Article number	16
Journal	Journal of Neuroinflammation
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s12974-016-0481-2
Publication status	Published - 2016

Keywords

Ficolin-1
Ficolin-2
Ficolin-3
Innate immunity
Ischemic stroke
Lectin pathway
MBL

ASJC Scopus subject areas

Neuroscience(all)
Cellular and Molecular Neuroscience
Neurology
Immunology

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Zangari, R., Roncati Zanier, E., Torgano, G. G., Bersano, A., Beretta, S., Beghi, E., Casolla, B., Checcarelli, N., Lanfranconi, S., Maino, A., Mandelli, C., Micieli, G., Orzi, F., Picetti, E., Silvestrini, M., Stocchetti, N., Zecca, B., Garred, P., & De Simoni, M. G. (2016). Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. Journal of Neuroinflammation, 13(1), [16]. https://doi.org/10.1186/s12974-016-0481-2

Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. / Zangari, R.; Roncati Zanier, Elisa ; Torgano, Giuseppe Gaudenzio ; Bersano, Anna; Beretta, Simone; Beghi, Ettore; Casolla, B.; Checcarelli, N.; Lanfranconi, Silvia; Maino, Alberto; Mandelli, C.; Micieli, Giuseppe; Orzi, Francesco; Picetti, Edoardo; Silvestrini, Mauro; Stocchetti, Nino; Zecca, B.; Garred, Peter; De Simoni, Maria Grazia.

In: Journal of Neuroinflammation, Vol. 13, No. 1, 16, 2016.

Research output: Contribution to journal › Article › peer-review

Zangari, R, Roncati Zanier, E , Torgano, GG , Bersano, A, Beretta, S, Beghi, E, Casolla, B, Checcarelli, N, Lanfranconi, S, Maino, A, Mandelli, C, Micieli, G, Orzi, F, Picetti, E, Silvestrini, M, Stocchetti, N, Zecca, B, Garred, P & De Simoni, MG 2016, 'Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke', Journal of Neuroinflammation, vol. 13, no. 1, 16. https://doi.org/10.1186/s12974-016-0481-2

Zangari, R. ; Roncati Zanier, Elisa ; Torgano, Giuseppe Gaudenzio ; Bersano, Anna ; Beretta, Simone ; Beghi, Ettore ; Casolla, B. ; Checcarelli, N. ; Lanfranconi, Silvia ; Maino, Alberto ; Mandelli, C. ; Micieli, Giuseppe ; Orzi, Francesco ; Picetti, Edoardo ; Silvestrini, Mauro ; Stocchetti, Nino ; Zecca, B. ; Garred, Peter ; De Simoni, Maria Grazia. / Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. In: Journal of Neuroinflammation. 2016 ; Vol. 13, No. 1.

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title = "Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke",

abstract = "Background: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke. Methods: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS). Results: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p <0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p <0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p <0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p <0.001 and ",

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AU - Zangari, R.

AU - Roncati Zanier, Elisa

AU - Torgano, Giuseppe Gaudenzio

AU - Bersano, Anna

AU - Beretta, Simone

AU - Beghi, Ettore

AU - Casolla, B.

AU - Checcarelli, N.

AU - Lanfranconi, Silvia

AU - Maino, Alberto

AU - Mandelli, C.

AU - Micieli, Giuseppe

AU - Orzi, Francesco

AU - Picetti, Edoardo

AU - Silvestrini, Mauro

AU - Stocchetti, Nino

AU - Zecca, B.

AU - Garred, Peter

AU - De Simoni, Maria Grazia

PY - 2016

Y1 - 2016

N2 - Background: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke. Methods: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS). Results: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p <0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p <0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p <0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p <0.001 and

AB - Background: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke. Methods: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS). Results: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p <0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p <0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p <0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p <0.001 and

KW - Ficolin-1

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KW - Ficolin-3

KW - Innate immunity

KW - Ischemic stroke

KW - Lectin pathway

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