Early fractures and occult hyperthyroidism: McCune-Albright syndrome?

Stefania Di Candia, Giovanna Weber, Stefano Mora, Maurizio De Pellegrin, Giuseppe Chiumello

Research output: Contribution to journalArticlepeer-review


McCune-Albright syndrome (MAS) is a sporadic disease characterized by fibrous bone dysplasia, café-au-lait spots and hyperfunctional endocrinopathies. We report a 2.5-year-old child with MAS with an early and nonclassic onset. He was admitted to our attention for frequent fractures without clinical signs of endocrinopathies, found to have asymptomatic, nonautoimmune hyperthyroidism. The diagnosis of MAS was based on RX and MR imaging associated with hyperthyroidism. It is not clear if there was a correlation between the severity of bone disease and the presence of thyroid disorder. At the moment no standard treatment exists for bone fibrous dysplasia and hyperthyroidism in children before the age of 6 years.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalHormone Research
Issue number1-2
Publication statusPublished - 2001


  • Fibrous dysplasia
  • Fractures
  • Hyperthyroidism
  • McCune-Albright syndrome
  • Pamidronate treatment
  • Pigmentation

ASJC Scopus subject areas

  • Endocrinology


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