Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

Alain Rudiger, Alex Dyson, Karen Felsmann, Jane E. Carré, Valerie Taylor, Sian Hughes, Innes Clatworthy, Alessandro Protti, Denis Pellerin, Jana Lemm, Ralf A. Claus, Michael Bauer, Mervyn Singer

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Myocardial function is depressed in sepsis and is an important prognosticator in the human condition. Using echocardiography in a long-term fluid-resuscitated Wistar rat model of faecal peritonitis we investigated whether depressed myocardial function could be detected at an early stage of sepsis and, if so, whether the degree of depression could predict eventual outcome. At 6 h post-insult, a stroke volume

Original languageEnglish
Pages (from-to)391-401
Number of pages11
JournalClinical Science
Volume124
Issue number6
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Sepsis
Myocardium
Peritonitis
Stroke Volume
Echocardiography
Wistar Rats

Keywords

  • Animal model
  • Echocardiography
  • Faecal peritonitis
  • Gene transcript
  • Heart failure
  • Sepsis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rudiger, A., Dyson, A., Felsmann, K., Carré, J. E., Taylor, V., Hughes, S., ... Singer, M. (2013). Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. Clinical Science, 124(6), 391-401. https://doi.org/10.1042/CS20120334

Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. / Rudiger, Alain; Dyson, Alex; Felsmann, Karen; Carré, Jane E.; Taylor, Valerie; Hughes, Sian; Clatworthy, Innes; Protti, Alessandro; Pellerin, Denis; Lemm, Jana; Claus, Ralf A.; Bauer, Michael; Singer, Mervyn.

In: Clinical Science, Vol. 124, No. 6, 03.2013, p. 391-401.

Research output: Contribution to journalArticle

Rudiger, A, Dyson, A, Felsmann, K, Carré, JE, Taylor, V, Hughes, S, Clatworthy, I, Protti, A, Pellerin, D, Lemm, J, Claus, RA, Bauer, M & Singer, M 2013, 'Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis', Clinical Science, vol. 124, no. 6, pp. 391-401. https://doi.org/10.1042/CS20120334
Rudiger, Alain ; Dyson, Alex ; Felsmann, Karen ; Carré, Jane E. ; Taylor, Valerie ; Hughes, Sian ; Clatworthy, Innes ; Protti, Alessandro ; Pellerin, Denis ; Lemm, Jana ; Claus, Ralf A. ; Bauer, Michael ; Singer, Mervyn. / Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. In: Clinical Science. 2013 ; Vol. 124, No. 6. pp. 391-401.
@article{4feca68a00444f73849002ce5e12f36c,
title = "Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis",
abstract = "Myocardial function is depressed in sepsis and is an important prognosticator in the human condition. Using echocardiography in a long-term fluid-resuscitated Wistar rat model of faecal peritonitis we investigated whether depressed myocardial function could be detected at an early stage of sepsis and, if so, whether the degree of depression could predict eventual outcome. At 6 h post-insult, a stroke volume",
keywords = "Animal model, Echocardiography, Faecal peritonitis, Gene transcript, Heart failure, Sepsis",
author = "Alain Rudiger and Alex Dyson and Karen Felsmann and Carr{\'e}, {Jane E.} and Valerie Taylor and Sian Hughes and Innes Clatworthy and Alessandro Protti and Denis Pellerin and Jana Lemm and Claus, {Ralf A.} and Michael Bauer and Mervyn Singer",
year = "2013",
month = "3",
doi = "10.1042/CS20120334",
language = "English",
volume = "124",
pages = "391--401",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "6",

}

TY - JOUR

T1 - Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

AU - Rudiger, Alain

AU - Dyson, Alex

AU - Felsmann, Karen

AU - Carré, Jane E.

AU - Taylor, Valerie

AU - Hughes, Sian

AU - Clatworthy, Innes

AU - Protti, Alessandro

AU - Pellerin, Denis

AU - Lemm, Jana

AU - Claus, Ralf A.

AU - Bauer, Michael

AU - Singer, Mervyn

PY - 2013/3

Y1 - 2013/3

N2 - Myocardial function is depressed in sepsis and is an important prognosticator in the human condition. Using echocardiography in a long-term fluid-resuscitated Wistar rat model of faecal peritonitis we investigated whether depressed myocardial function could be detected at an early stage of sepsis and, if so, whether the degree of depression could predict eventual outcome. At 6 h post-insult, a stroke volume

AB - Myocardial function is depressed in sepsis and is an important prognosticator in the human condition. Using echocardiography in a long-term fluid-resuscitated Wistar rat model of faecal peritonitis we investigated whether depressed myocardial function could be detected at an early stage of sepsis and, if so, whether the degree of depression could predict eventual outcome. At 6 h post-insult, a stroke volume

KW - Animal model

KW - Echocardiography

KW - Faecal peritonitis

KW - Gene transcript

KW - Heart failure

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=84872224797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872224797&partnerID=8YFLogxK

U2 - 10.1042/CS20120334

DO - 10.1042/CS20120334

M3 - Article

VL - 124

SP - 391

EP - 401

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 6

ER -