Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

Alain Rudiger, Alex Dyson, Karen Felsmann, Jane E. Carré, Valerie Taylor, Sian Hughes, Innes Clatworthy, Alessandro Protti, Denis Pellerin, Jana Lemm, Ralf A. Claus, Michael Bauer, Mervyn Singer

Research output: Contribution to journalArticle

Abstract

Myocardial function is depressed in sepsis and is an important prognosticator in the human condition. Using echocardiography in a long-term fluid-resuscitated Wistar rat model of faecal peritonitis we investigated whether depressed myocardial function could be detected at an early stage of sepsis and, if so, whether the degree of depression could predict eventual outcome. At 6 h post-insult, a stroke volume

Original languageEnglish
Pages (from-to)391-401
Number of pages11
JournalClinical Science
Volume124
Issue number6
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Animal model
  • Echocardiography
  • Faecal peritonitis
  • Gene transcript
  • Heart failure
  • Sepsis

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Rudiger, A., Dyson, A., Felsmann, K., Carré, J. E., Taylor, V., Hughes, S., Clatworthy, I., Protti, A., Pellerin, D., Lemm, J., Claus, R. A., Bauer, M., & Singer, M. (2013). Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. Clinical Science, 124(6), 391-401. https://doi.org/10.1042/CS20120334