Abstract
Nerve growth factor (NGF) induces the chromaffin cell line PC12 to differentiate into cells with many of the properties of sympathetic neurons. We investigated the early differentiative phase and identified a gene, PC4, rapidly and transiently induced by NGF in PC12 cells. PC4 cDNA is homologous to the partial sequence of a putative mouse β-interferon and encodes a protein related to a lymphokine, the rat γ-interferon protein. Nonetheless, PC4 appears devoid of antiviral activity. PC4 is expressed in proliferating and differentiating tissues, such as amnion, placenta, and brain at embryonic day 13.5. The relationship of PC4 to interferons and lymphokines suggests that it could play a role in regulating gene activity in the pathways induced by NGF.
| Original language | English |
|---|---|
| Pages (from-to) | 2088-2092 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 86 |
| Issue number | 6 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- General
- Genetics
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Early gene regulation by nerve growth factor in PC12 cells : Induction of an interferon-related gene. / Tirone, F.; Shooter, E. M.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 6, 1989, p. 2088-2092.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early gene regulation by nerve growth factor in PC12 cells
T2 - Induction of an interferon-related gene
AU - Tirone, F.
AU - Shooter, E. M.
PY - 1989
Y1 - 1989
N2 - Nerve growth factor (NGF) induces the chromaffin cell line PC12 to differentiate into cells with many of the properties of sympathetic neurons. We investigated the early differentiative phase and identified a gene, PC4, rapidly and transiently induced by NGF in PC12 cells. PC4 cDNA is homologous to the partial sequence of a putative mouse β-interferon and encodes a protein related to a lymphokine, the rat γ-interferon protein. Nonetheless, PC4 appears devoid of antiviral activity. PC4 is expressed in proliferating and differentiating tissues, such as amnion, placenta, and brain at embryonic day 13.5. The relationship of PC4 to interferons and lymphokines suggests that it could play a role in regulating gene activity in the pathways induced by NGF.
AB - Nerve growth factor (NGF) induces the chromaffin cell line PC12 to differentiate into cells with many of the properties of sympathetic neurons. We investigated the early differentiative phase and identified a gene, PC4, rapidly and transiently induced by NGF in PC12 cells. PC4 cDNA is homologous to the partial sequence of a putative mouse β-interferon and encodes a protein related to a lymphokine, the rat γ-interferon protein. Nonetheless, PC4 appears devoid of antiviral activity. PC4 is expressed in proliferating and differentiating tissues, such as amnion, placenta, and brain at embryonic day 13.5. The relationship of PC4 to interferons and lymphokines suggests that it could play a role in regulating gene activity in the pathways induced by NGF.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024556705&partnerID=8YFLogxK
M3 - Article
VL - 86
SP - 2088
EP - 2092
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 6
ER -