Early glycoxidation damage in brains from Down's syndrome

Patrizio Odetti, Giovanna Angelini, Debora Dapino, Damiano Zaccheo, Silvano Garibaldi, Francesca Dagna-Bricarelli, Giuseppe Piombo, George Perry, Mark Smith, Nicola Traverso, Massimo Tabaton

Research output: Contribution to journalArticlepeer-review


In Down's syndrome, the presence of three copies of chromosome 21 is associated with premature aging and progressive mental retardation sharing the pathological features of Alzheimer disease. Early cortical dysgenesis and late neuronal degeneration are probably caused by an overproduction of amyloid β-peptide, followed by an increased cellular oxidation. Interestingly, chromosome 21 codes for superoxide-dismutase and amyloid β precursor resulting, in Down's syndrome, in an overflow of these gene products and metabolites. We studied Down's fetal brain cortex to evaluate the presence and amount of lipid and protein oxidation markers; moreover, we quantified two forms of glycation end products that are known to be involved in the process of cellular oxidation. All these parameters are significantly increased in Down's fetal brains in comparison to controls, providing the evidence that accelerated brain glycoxidation occurs very early in the life of Down's syndrome subjects.

Original languageEnglish
Pages (from-to)849-851
Number of pages3
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Feb 24 1998

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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