Early graft injurie, after pancreatic transplantation insyngeneic rats - Cytoprotective effects of gabexate-mesilate

Claudio Bassi, Luigi Benetti, Roberto Girelli, Massimo Falconi, Filippo Nifosí, Girolarno Coviello, Giorgio Cavallini, Sergio Vesentini, Carola Dragonetti, Paolo Pederzoli

Research output: Contribution to journalArticle

Abstract

Failure, in experimental and human pancreatic transplantation are mainly attributable to rejection, graft thrombosis, and technical problems. There are, however, problem, related to other causes, such as preservation injuries, which we found to exhibit, at least within the first 6 h, the same histological patternsseen in experimental acute pancreatitis. We performed pancreatic transplantation in 110 syngeneic rat, under different preservation technique, and administration of gabexate mesilate, a synthetic protease inhibitor. The results showed that antiprotease treatment reduce, graft preservation injuries significantly.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalInternational Journal of Pancreatology
Volume8
Issue number4
DOIs
Publication statusPublished - May 1991

Keywords

  • gabexate mesilate
  • Pancrea transplantation
  • pancreatitis
  • preservation injuries

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

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    Bassi, C., Benetti, L., Girelli, R., Falconi, M., Nifosí, F., Coviello, G., Cavallini, G., Vesentini, S., Dragonetti, C., & Pederzoli, P. (1991). Early graft injurie, after pancreatic transplantation insyngeneic rats - Cytoprotective effects of gabexate-mesilate. International Journal of Pancreatology, 8(4), 345-353. https://doi.org/10.1007/BF02952726