Early HER2 dysregulation in gastric and oesophageal carcinogenesis

Matteo Fassan; Luca Mastracci; Federica Grillo; Vittorina Zagonel; Sara Bruno; Giorgio Battaglia; Francesca Pitto; Donato Nitti; Tiziana Celiento; Giovanni Zaninotto; Roberto Fiocca; Massimo Rugge

doi:10.1111/j.1365-2559.2012.04272.x

Early HER2 dysregulation in gastric and oesophageal carcinogenesis

Matteo Fassan, Luca Mastracci, Federica Grillo, Vittorina Zagonel, Sara Bruno, Giorgio Battaglia, Francesca Pitto, Donato Nitti, Tiziana Celiento, Giovanni Zaninotto, Roberto Fiocca, Massimo Rugge

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: To explore human epidermal growth factor receptor 2 (HER2) status in the histological phenotypes [metaplasia, intraepithelial neoplasia (IEN, i.e. dysplasia), and adenocarcinoma] involved in the morphogenesis of both intestinal-type gastric cancer (GC) and Barrett's adenocarcinoma (BAc). Methods and results: A consecutive series of 275 samples of stomach and oesophagus tissue (representing the whole spectrum of the phenotypic changes involved in gastric and Barrett's carcinogenesis) was studied. HER2 status was assessed by applying two immunohistochemistry (IHC) protocols, using the antibodies 4B5 and CB11. Dual-colour silver chromogenic in-situ hybridization (SISH) was also performed on the same tissue samples. In both oesophageal and gastric samples, the rate of HER2 overexpression rose significantly from low-grade to high-grade IEN to adenocarcinoma (P

Original language	English
Pages (from-to)	769-776
Number of pages	8
Journal	Histopathology
Volume	61
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2559.2012.04272.x
Publication status	Published - Nov 2012

Keywords

Carcinogenesis
Dysplasia
HER2
Immunohistochemistry
SISH

ASJC Scopus subject areas

Histology
Pathology and Forensic Medicine

Access to Document

10.1111/j.1365-2559.2012.04272.x

Cite this

@article{eec2b637a554429db25e88cea687a2c4,

title = "Early HER2 dysregulation in gastric and oesophageal carcinogenesis",

abstract = "Aims: To explore human epidermal growth factor receptor 2 (HER2) status in the histological phenotypes [metaplasia, intraepithelial neoplasia (IEN, i.e. dysplasia), and adenocarcinoma] involved in the morphogenesis of both intestinal-type gastric cancer (GC) and Barrett's adenocarcinoma (BAc). Methods and results: A consecutive series of 275 samples of stomach and oesophagus tissue (representing the whole spectrum of the phenotypic changes involved in gastric and Barrett's carcinogenesis) was studied. HER2 status was assessed by applying two immunohistochemistry (IHC) protocols, using the antibodies 4B5 and CB11. Dual-colour silver chromogenic in-situ hybridization (SISH) was also performed on the same tissue samples. In both oesophageal and gastric samples, the rate of HER2 overexpression rose significantly from low-grade to high-grade IEN to adenocarcinoma (P",

keywords = "Carcinogenesis, Dysplasia, HER2, Immunohistochemistry, SISH",

author = "Matteo Fassan and Luca Mastracci and Federica Grillo and Vittorina Zagonel and Sara Bruno and Giorgio Battaglia and Francesca Pitto and Donato Nitti and Tiziana Celiento and Giovanni Zaninotto and Roberto Fiocca and Massimo Rugge",

year = "2012",

month = nov,

doi = "10.1111/j.1365-2559.2012.04272.x",

language = "English",

volume = "61",

pages = "769--776",

journal = "Histopathology",

issn = "0309-0167",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Early HER2 dysregulation in gastric and oesophageal carcinogenesis

AU - Fassan, Matteo

AU - Mastracci, Luca

AU - Grillo, Federica

AU - Zagonel, Vittorina

AU - Bruno, Sara

AU - Battaglia, Giorgio

AU - Pitto, Francesca

AU - Nitti, Donato

AU - Celiento, Tiziana

AU - Zaninotto, Giovanni

AU - Fiocca, Roberto

AU - Rugge, Massimo

PY - 2012/11

Y1 - 2012/11

N2 - Aims: To explore human epidermal growth factor receptor 2 (HER2) status in the histological phenotypes [metaplasia, intraepithelial neoplasia (IEN, i.e. dysplasia), and adenocarcinoma] involved in the morphogenesis of both intestinal-type gastric cancer (GC) and Barrett's adenocarcinoma (BAc). Methods and results: A consecutive series of 275 samples of stomach and oesophagus tissue (representing the whole spectrum of the phenotypic changes involved in gastric and Barrett's carcinogenesis) was studied. HER2 status was assessed by applying two immunohistochemistry (IHC) protocols, using the antibodies 4B5 and CB11. Dual-colour silver chromogenic in-situ hybridization (SISH) was also performed on the same tissue samples. In both oesophageal and gastric samples, the rate of HER2 overexpression rose significantly from low-grade to high-grade IEN to adenocarcinoma (P

AB - Aims: To explore human epidermal growth factor receptor 2 (HER2) status in the histological phenotypes [metaplasia, intraepithelial neoplasia (IEN, i.e. dysplasia), and adenocarcinoma] involved in the morphogenesis of both intestinal-type gastric cancer (GC) and Barrett's adenocarcinoma (BAc). Methods and results: A consecutive series of 275 samples of stomach and oesophagus tissue (representing the whole spectrum of the phenotypic changes involved in gastric and Barrett's carcinogenesis) was studied. HER2 status was assessed by applying two immunohistochemistry (IHC) protocols, using the antibodies 4B5 and CB11. Dual-colour silver chromogenic in-situ hybridization (SISH) was also performed on the same tissue samples. In both oesophageal and gastric samples, the rate of HER2 overexpression rose significantly from low-grade to high-grade IEN to adenocarcinoma (P

KW - Carcinogenesis

KW - Dysplasia

KW - HER2

KW - Immunohistochemistry

KW - SISH

UR - http://www.scopus.com/inward/record.url?scp=84868122631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868122631&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2559.2012.04272.x

DO - 10.1111/j.1365-2559.2012.04272.x

M3 - Article

C2 - 22882541

AN - SCOPUS:84868122631

VL - 61

SP - 769

EP - 776

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 5

ER -

Early HER2 dysregulation in gastric and oesophageal carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this