Early HER2 dysregulation in gastric and oesophageal carcinogenesis

Matteo Fassan, Luca Mastracci, Federica Grillo, Vittorina Zagonel, Sara Bruno, Giorgio Battaglia, Francesca Pitto, Donato Nitti, Tiziana Celiento, Giovanni Zaninotto, Roberto Fiocca, Massimo Rugge

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To explore human epidermal growth factor receptor 2 (HER2) status in the histological phenotypes [metaplasia, intraepithelial neoplasia (IEN, i.e. dysplasia), and adenocarcinoma] involved in the morphogenesis of both intestinal-type gastric cancer (GC) and Barrett's adenocarcinoma (BAc). Methods and results: A consecutive series of 275 samples of stomach and oesophagus tissue (representing the whole spectrum of the phenotypic changes involved in gastric and Barrett's carcinogenesis) was studied. HER2 status was assessed by applying two immunohistochemistry (IHC) protocols, using the antibodies 4B5 and CB11. Dual-colour silver chromogenic in-situ hybridization (SISH) was also performed on the same tissue samples. In both oesophageal and gastric samples, the rate of HER2 overexpression rose significantly from low-grade to high-grade IEN to adenocarcinoma (P

Original languageEnglish
Pages (from-to)769-776
Number of pages8
JournalHistopathology
Volume61
Issue number5
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Carcinogenesis
  • Dysplasia
  • HER2
  • Immunohistochemistry
  • SISH

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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