Abstract
Aims: To explore human epidermal growth factor receptor 2 (HER2) status in the histological phenotypes [metaplasia, intraepithelial neoplasia (IEN, i.e. dysplasia), and adenocarcinoma] involved in the morphogenesis of both intestinal-type gastric cancer (GC) and Barrett's adenocarcinoma (BAc). Methods and results: A consecutive series of 275 samples of stomach and oesophagus tissue (representing the whole spectrum of the phenotypic changes involved in gastric and Barrett's carcinogenesis) was studied. HER2 status was assessed by applying two immunohistochemistry (IHC) protocols, using the antibodies 4B5 and CB11. Dual-colour silver chromogenic in-situ hybridization (SISH) was also performed on the same tissue samples. In both oesophageal and gastric samples, the rate of HER2 overexpression rose significantly from low-grade to high-grade IEN to adenocarcinoma (P
| Original language | English |
|---|---|
| Pages (from-to) | 769-776 |
| Number of pages | 8 |
| Journal | Histopathology |
| Volume | 61 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 2012 |
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Keywords
- Carcinogenesis
- Dysplasia
- HER2
- Immunohistochemistry
- SISH
ASJC Scopus subject areas
- Histology
- Pathology and Forensic Medicine
Cite this
Early HER2 dysregulation in gastric and oesophageal carcinogenesis. / Fassan, Matteo; Mastracci, Luca; Grillo, Federica; Zagonel, Vittorina; Bruno, Sara; Battaglia, Giorgio; Pitto, Francesca; Nitti, Donato; Celiento, Tiziana; Zaninotto, Giovanni; Fiocca, Roberto; Rugge, Massimo.
In: Histopathology, Vol. 61, No. 5, 11.2012, p. 769-776.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early HER2 dysregulation in gastric and oesophageal carcinogenesis
AU - Fassan, Matteo
AU - Mastracci, Luca
AU - Grillo, Federica
AU - Zagonel, Vittorina
AU - Bruno, Sara
AU - Battaglia, Giorgio
AU - Pitto, Francesca
AU - Nitti, Donato
AU - Celiento, Tiziana
AU - Zaninotto, Giovanni
AU - Fiocca, Roberto
AU - Rugge, Massimo
PY - 2012/11
Y1 - 2012/11
N2 - Aims: To explore human epidermal growth factor receptor 2 (HER2) status in the histological phenotypes [metaplasia, intraepithelial neoplasia (IEN, i.e. dysplasia), and adenocarcinoma] involved in the morphogenesis of both intestinal-type gastric cancer (GC) and Barrett's adenocarcinoma (BAc). Methods and results: A consecutive series of 275 samples of stomach and oesophagus tissue (representing the whole spectrum of the phenotypic changes involved in gastric and Barrett's carcinogenesis) was studied. HER2 status was assessed by applying two immunohistochemistry (IHC) protocols, using the antibodies 4B5 and CB11. Dual-colour silver chromogenic in-situ hybridization (SISH) was also performed on the same tissue samples. In both oesophageal and gastric samples, the rate of HER2 overexpression rose significantly from low-grade to high-grade IEN to adenocarcinoma (P
AB - Aims: To explore human epidermal growth factor receptor 2 (HER2) status in the histological phenotypes [metaplasia, intraepithelial neoplasia (IEN, i.e. dysplasia), and adenocarcinoma] involved in the morphogenesis of both intestinal-type gastric cancer (GC) and Barrett's adenocarcinoma (BAc). Methods and results: A consecutive series of 275 samples of stomach and oesophagus tissue (representing the whole spectrum of the phenotypic changes involved in gastric and Barrett's carcinogenesis) was studied. HER2 status was assessed by applying two immunohistochemistry (IHC) protocols, using the antibodies 4B5 and CB11. Dual-colour silver chromogenic in-situ hybridization (SISH) was also performed on the same tissue samples. In both oesophageal and gastric samples, the rate of HER2 overexpression rose significantly from low-grade to high-grade IEN to adenocarcinoma (P
KW - Carcinogenesis
KW - Dysplasia
KW - HER2
KW - Immunohistochemistry
KW - SISH
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UR - http://www.scopus.com/inward/citedby.url?scp=84868122631&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2559.2012.04272.x
DO - 10.1111/j.1365-2559.2012.04272.x
M3 - Article
VL - 61
SP - 769
EP - 776
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 5
ER -