Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming

Francesca Granucci, Sonia Feau, Véronique Angeli, François Trottein, Paola Ricciardi-Castagnoli

Research output: Contribution to journalArticlepeer-review


Dendritic cells (DCs) are professional APCs able to initiate innate and adaptive immune responses against invading pathogens. Different properties such as the efficient Ag processing machinery, the high levels of expression of costimulatory molecules and peptide-MHC complexes, and the production of cytokines contribute in making DCs potent stimulators of naive T cell responses. Recently we have observed that DCs are able to produce IL-2 following bacterial stimulation, and we have demonstrated that this particular cytokine is a key molecule conferring to early bacterial activated DCs unique T cell priming capacity. In the present study we show that many different microbial stimuli, but not inflammatory cytokines, are able to stimulate DCs to produce IL-2, indicating that DCs can distinguish a cytokine-mediated inflammatory process from the actual presence of an infection. The capacity to produce IL-2 following a microbial stimuli encounter is a feature shared by diverse DC subtypes in vivo, such as CD8α+ and CD8α- splenic DCs and epidermal Langerhans cells. When early activated DCs interact with T cells, IL-2 produced by DCs is enriched at the site of cell-cell contact, confirming the importance of DCs-derived IL-2 in T cell activation.

Original languageEnglish
Pages (from-to)5075-5081
Number of pages7
JournalJournal of Immunology
Issue number10
Publication statusPublished - May 15 2003

ASJC Scopus subject areas

  • Immunology


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