Early immunisation with hepatitis B vaccine: A five-year study

Cesare Belloni, Angela Pistorio, Carmine Tinelli, Jacqueline Komakec, Gaetano Chirico, Daniela Rovelli, Roberto Gulminetti, Giuditta Comolli, Paolo Orsolini, Giorgio Rondini

Research output: Contribution to journalArticlepeer-review


We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.

Original languageEnglish
Pages (from-to)1307-1311
Number of pages5
Issue number14
Publication statusPublished - Feb 4 2000


  • Hepatitis B vaccines
  • Immunisation schedule
  • Immunologic memory

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)


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