Early immunisation with hepatitis B vaccine

A five-year study

Cesare Belloni, Angela Pistorio, Carmine Tinelli, Jacqueline Komakec, Gaetano Chirico, Daniela Rovelli, Roberto Gulminetti, Giuditta Comolli, Paolo Orsolini, Giorgio Rondini

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.

Original languageEnglish
Pages (from-to)1307-1311
Number of pages5
JournalVaccine
Volume18
Issue number14
DOIs
Publication statusPublished - Feb 4 2000

Fingerprint

hepatitis B
Immunization
Appointments and Schedules
immunization
Immunologic Memory
vaccines
Synthetic Vaccines
seroconversion
recombinant vaccines
Hepatitis B Vaccines
Long-Term Memory
Hepatitis B Surface Antigens
antibodies
Mothers
dosage
twinrix
Antibodies
Serum
immunologic memory

Keywords

  • Hepatitis B vaccines
  • Immunisation schedule
  • Immunologic memory

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Belloni, C., Pistorio, A., Tinelli, C., Komakec, J., Chirico, G., Rovelli, D., ... Rondini, G. (2000). Early immunisation with hepatitis B vaccine: A five-year study. Vaccine, 18(14), 1307-1311. https://doi.org/10.1016/S0264-410X(99)00414-4

Early immunisation with hepatitis B vaccine : A five-year study. / Belloni, Cesare; Pistorio, Angela; Tinelli, Carmine; Komakec, Jacqueline; Chirico, Gaetano; Rovelli, Daniela; Gulminetti, Roberto; Comolli, Giuditta; Orsolini, Paolo; Rondini, Giorgio.

In: Vaccine, Vol. 18, No. 14, 04.02.2000, p. 1307-1311.

Research output: Contribution to journalArticle

Belloni, Cesare ; Pistorio, Angela ; Tinelli, Carmine ; Komakec, Jacqueline ; Chirico, Gaetano ; Rovelli, Daniela ; Gulminetti, Roberto ; Comolli, Giuditta ; Orsolini, Paolo ; Rondini, Giorgio. / Early immunisation with hepatitis B vaccine : A five-year study. In: Vaccine. 2000 ; Vol. 18, No. 14. pp. 1307-1311.
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