Early immunisation with hepatitis B vaccine: A five-year study

Cesare Belloni; Angela Pistorio; Carmine Tinelli; Jacqueline Komakec; Gaetano Chirico; Daniela Rovelli; Roberto Gulminetti; Giuditta Comolli; Paolo Orsolini; Giorgio Rondini

doi:10.1016/S0264-410X(99)00414-4

Early immunisation with hepatitis B vaccine: A five-year study

Cesare Belloni, Angela Pistorio, Carmine Tinelli, Jacqueline Komakec, Gaetano Chirico, Daniela Rovelli, Roberto Gulminetti, Giuditta Comolli, Paolo Orsolini, Giorgio Rondini

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.

Original language	English
Pages (from-to)	1307-1311
Number of pages	5
Journal	Vaccine
Volume	18
Issue number	14
DOIs	https://doi.org/10.1016/S0264-410X(99)00414-4
Publication status	Published - Feb 4 2000

Keywords

Hepatitis B vaccines
Immunisation schedule
Immunologic memory

ASJC Scopus subject areas

Immunology
Microbiology
Virology
Infectious Diseases
Public Health, Environmental and Occupational Health
veterinary(all)

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10.1016/S0264-410X(99)00414-4

Cite this

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title = "Early immunisation with hepatitis B vaccine: A five-year study",

abstract = "We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.",

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T2 - A five-year study

AU - Belloni, Cesare

AU - Pistorio, Angela

AU - Tinelli, Carmine

AU - Komakec, Jacqueline

AU - Chirico, Gaetano

AU - Rovelli, Daniela

AU - Gulminetti, Roberto

AU - Comolli, Giuditta

AU - Orsolini, Paolo

AU - Rondini, Giorgio

PY - 2000/2/4

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N2 - We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.

AB - We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.

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KW - Immunisation schedule

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Early immunisation with hepatitis B vaccine: A five-year study

Abstract

Keywords

ASJC Scopus subject areas

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