Abstract
We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.
| Original language | English |
|---|---|
| Pages (from-to) | 1307-1311 |
| Number of pages | 5 |
| Journal | Vaccine |
| Volume | 18 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Feb 4 2000 |
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Keywords
- Hepatitis B vaccines
- Immunisation schedule
- Immunologic memory
ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)
Cite this
Early immunisation with hepatitis B vaccine : A five-year study. / Belloni, Cesare; Pistorio, Angela; Tinelli, Carmine; Komakec, Jacqueline; Chirico, Gaetano; Rovelli, Daniela; Gulminetti, Roberto; Comolli, Giuditta; Orsolini, Paolo; Rondini, Giorgio.
In: Vaccine, Vol. 18, No. 14, 04.02.2000, p. 1307-1311.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early immunisation with hepatitis B vaccine
T2 - A five-year study
AU - Belloni, Cesare
AU - Pistorio, Angela
AU - Tinelli, Carmine
AU - Komakec, Jacqueline
AU - Chirico, Gaetano
AU - Rovelli, Daniela
AU - Gulminetti, Roberto
AU - Comolli, Giuditta
AU - Orsolini, Paolo
AU - Rondini, Giorgio
PY - 2000/2/4
Y1 - 2000/2/4
N2 - We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.
AB - We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.
KW - Hepatitis B vaccines
KW - Immunisation schedule
KW - Immunologic memory
UR - http://www.scopus.com/inward/record.url?scp=0033985519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033985519&partnerID=8YFLogxK
U2 - 10.1016/S0264-410X(99)00414-4
DO - 10.1016/S0264-410X(99)00414-4
M3 - Article
VL - 18
SP - 1307
EP - 1311
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 14
ER -