Early immunisation with hepatitis B vaccine: A five-year study

Cesare Belloni; Angela Pistorio; Carmine Tinelli; Jacqueline Komakec; Gaetano Chirico; Daniela Rovelli; Roberto Gulminetti; Giuditta Comolli; Paolo Orsolini; Giorgio Rondini

doi:10.1016/S0264-410X(99)00414-4

Early immunisation with hepatitis B vaccine: A five-year study

Cesare Belloni, Angela Pistorio, Carmine Tinelli, Jacqueline Komakec, Gaetano Chirico, Daniela Rovelli, Roberto Gulminetti, Giuditta Comolli, Paolo Orsolini, Giorgio Rondini

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.

Original language	English
Pages (from-to)	1307-1311
Number of pages	5
Journal	Vaccine
Volume	18
Issue number	14
DOIs	https://doi.org/10.1016/S0264-410X(99)00414-4
Publication status	Published - Feb 4 2000

Keywords

Hepatitis B vaccines
Immunisation schedule
Immunologic memory

ASJC Scopus subject areas

Immunology
Microbiology
Virology
Infectious Diseases
Public Health, Environmental and Occupational Health
veterinary(all)

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10.1016/S0264-410X(99)00414-4

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Early immunisation with hepatitis B vaccine : A five-year study. / Belloni, Cesare; Pistorio, Angela ; Tinelli, Carmine; Komakec, Jacqueline; Chirico, Gaetano; Rovelli, Daniela; Gulminetti, Roberto ; Comolli, Giuditta ; Orsolini, Paolo; Rondini, Giorgio.

In: Vaccine, Vol. 18, No. 14, 04.02.2000, p. 1307-1311.

Research output: Contribution to journal › Article › peer-review

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AU - Rovelli, Daniela

AU - Gulminetti, Roberto

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Early immunisation with hepatitis B vaccine: A five-year study

Abstract

Keywords

ASJC Scopus subject areas

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