Abstract
We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier.
Original language | English |
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Pages (from-to) | 1307-1311 |
Number of pages | 5 |
Journal | Vaccine |
Volume | 18 |
Issue number | 14 |
DOIs | |
Publication status | Published - Feb 4 2000 |
Keywords
- Hepatitis B vaccines
- Immunisation schedule
- Immunologic memory
ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)