Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome

Francesco Orio, Stefano Palomba, Teresa Cascella, Biagio De Simone, Sebastiano Di Biase, Tiziana Russo, Donato Labella, Fulvio Zullo, Gaetano Lombardi, Annamaria Colao

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the presence of early vascular damage in young normal-weight women with polycystic ovary syndrome (PCOS). Thirty young normal-weight women with PCOS, who had no additional metabolic or cardiovascular diseases, and 30 healthy women (controls) matched for age and body mass index were studied. A complete hormonal assay was performed in each subject. Serum insulin and glucose levels were measured at baseline and after the oral glucose tolerance test. Plasma endothelin-1 levels and serum lipid profile were also assessed. The endothelial function was studied by flow-mediated dilation on the brachial artery, and arterial structure was evaluated by intima-media thickness measurement using Doppler ultrasound of both common carotid arteries. A significant (P <0.05) difference in flow-mediated dilation (14.3 ± 1.9% vs. 18.1 ± 2.0% for PCOS patients and controls, respectively) and in intima-media thickness (0.53 ± 0.09 mm vs. 0.39 ± 0.08 mm for PCOS patients and controls, respectively) was found between PCOS and control subjects. Serum endothelin-1 levels were also significantly (P <0.05) higher in PCOS patients compared with controls (1.1 ± 0.4 pmol/liter vs. 0.5 ± 0.2 pmol/liter for PCOS patients and controls, respectively). In conclusion, our data show that young, normal-weight, nondyslipidemic, nonhypertensive women with PCOS have an early impairment of endothelial structure and function.

Original languageEnglish
Pages (from-to)4588-4593
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number9
DOIs
Publication statusPublished - Sep 2004

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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