Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome

Francesco Orio, Stefano Palomba, Teresa Cascella, Biagio De Simone, Sebastiano Di Biase, Tiziana Russo, Donato Labella, Fulvio Zullo, Gaetano Lombardi, Annamaria Colao

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate the presence of early vascular damage in young normal-weight women with polycystic ovary syndrome (PCOS). Thirty young normal-weight women with PCOS, who had no additional metabolic or cardiovascular diseases, and 30 healthy women (controls) matched for age and body mass index were studied. A complete hormonal assay was performed in each subject. Serum insulin and glucose levels were measured at baseline and after the oral glucose tolerance test. Plasma endothelin-1 levels and serum lipid profile were also assessed. The endothelial function was studied by flow-mediated dilation on the brachial artery, and arterial structure was evaluated by intima-media thickness measurement using Doppler ultrasound of both common carotid arteries. A significant (P <0.05) difference in flow-mediated dilation (14.3 ± 1.9% vs. 18.1 ± 2.0% for PCOS patients and controls, respectively) and in intima-media thickness (0.53 ± 0.09 mm vs. 0.39 ± 0.08 mm for PCOS patients and controls, respectively) was found between PCOS and control subjects. Serum endothelin-1 levels were also significantly (P <0.05) higher in PCOS patients compared with controls (1.1 ± 0.4 pmol/liter vs. 0.5 ± 0.2 pmol/liter for PCOS patients and controls, respectively). In conclusion, our data show that young, normal-weight, nondyslipidemic, nonhypertensive women with PCOS have an early impairment of endothelial structure and function.

Original languageEnglish
Pages (from-to)4588-4593
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number9
DOIs
Publication statusPublished - Sep 2004

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Polycystic Ovary Syndrome
Weights and Measures
Endothelin-1
Glucose
Dilatation
Thickness measurement
Serum
Doppler Ultrasonography
Brachial Artery
Assays
Common Carotid Artery
Metabolic Diseases
Glucose Tolerance Test
Ultrasonics
Insulin
Blood Vessels
Lipids
Plasmas
Body Mass Index
Cardiovascular Diseases

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome. / Orio, Francesco; Palomba, Stefano; Cascella, Teresa; De Simone, Biagio; Di Biase, Sebastiano; Russo, Tiziana; Labella, Donato; Zullo, Fulvio; Lombardi, Gaetano; Colao, Annamaria.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 9, 09.2004, p. 4588-4593.

Research output: Contribution to journalArticle

Orio, F, Palomba, S, Cascella, T, De Simone, B, Di Biase, S, Russo, T, Labella, D, Zullo, F, Lombardi, G & Colao, A 2004, 'Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 9, pp. 4588-4593. https://doi.org/10.1210/jc.2003-031867
Orio, Francesco ; Palomba, Stefano ; Cascella, Teresa ; De Simone, Biagio ; Di Biase, Sebastiano ; Russo, Tiziana ; Labella, Donato ; Zullo, Fulvio ; Lombardi, Gaetano ; Colao, Annamaria. / Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome. In: Journal of Clinical Endocrinology and Metabolism. 2004 ; Vol. 89, No. 9. pp. 4588-4593.
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